MDR1, MRP1 and MRP2 Genotypes and In Vitro Chemosensitivity in Japanese Patients with Colorectal Adenocarcinomas

Nishioka, Chiharu; Sakaeda, Toshiyuki; Nakamura, Tsutomu; Moriya, Yuka; Okamura, Noboru; Tamura, Takao; Nakahara, Takako; Aoyama, Nobuo; Kamigaki, Takashi; Ohno, Masakazu; Kuroda, Yoshikazu; Kasuga, Masato; Okumura, Katsuhiko

doi:https://doi.org/10.24546/00422052

https://doi.org/10.24546/00422052

このアイテムのアクセス数:80件（2026-08-11 08:37 集計）

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メタデータID	00422052
アクセス権	open access
出版タイプ	Version of Record
タイトル	MDR1, MRP1 and MRP2 Genotypes and In Vitro Chemosensitivity in Japanese Patients with Colorectal Adenocarcinomas
著者	Nishioka, Chiharu ; Sakaeda, Toshiyuki ; Nakamura, Tsutomu ; Moriya, Yuka ; Okamura, Noboru ; Tamura, Takao ; Nakahara, Takako ; Aoyama, Nobuo ; Kamigaki, Takashi ; Ohno, Masakazu ; Kuroda, Yoshikazu ; Kasuga, Masato ; Okumura, Katsuhiko
著者名 Nishioka, Chiharu
著者名 Sakaeda, Toshiyuki
著者名 Nakamura, Tsutomu
著者名 Moriya, Yuka
著者名 Okamura, Noboru
著者名 Tamura, Takao
著者名 Nakahara, Takako
著者名 Aoyama, Nobuo
著者名 Kamigaki, Takashi
著者名 Ohno, Masakazu
著者名 Kuroda, Yoshikazu
著者名 Kasuga, Masato
著者名 Okumura, Katsuhiko
言語	English (英語)
収録物名	The Kobe journal of the medical sciences
巻(号)	50(5/6)
ページ	181-188
出版者	神戸大学医学部
出版者	Kobe University School of Medicine
刊行日	2005-04
公開日	2006-07-15
抄録	In our previous paper, the chemosensitivity of human colorectal adenocarcinoma was evaluated against 12 anticancer drugs including 5-fluorouracil (5-FU), 7-ethyl-10-hydroxycamptothecin (SN-38), mitomycin C (MMC) and cisplatin (CDDP), and it was found that the anticancer drugs were effective against those with a relatively high growth rate. MMC was effective for those with a relatively high mRNA expression of the multidrug resistance-associated protein 2 (MRP2), whereas no correlation was found for the multidrug resistant transporter MDR1 and MRP1. In this study, 3 genotypes of MDR1, 4 genotypes of MRP1, and 6 genotypes of MRP2 were additionally evaluated, and it was suggested that MDR1 C3435T and MRP2 G1249A were related with the susceptibility to colorectal adenocarcinoma. The chemosensitivity against 5-FU, SN-38, MMC and CDDP was independent of MDR1 C3435T, MRP1 G2168A, and MRP2 C-24T (C3972T), possibly due to no association with the growth rate of and mRNA expression levels of MDR1, MRP1 and MRP2 in the adenocarcinoma, however, MDR1 C3435T tended to be accompanied with a higher expression of MDR1 mRNA.
キーワード	Chemosensitivity
	CD-DST
	human colorectal adenocarcinomas
	MDR1
	MRP1
	MRP2
カテゴリ	The Kobe journal of the medical sciences ＞ 50巻＞ 50巻6号（2004）
カテゴリ	紀要論文
関連情報	NAID 110001874634　CiNiiで表示
関連情報	URI http://www.med.kobe-u.ac.jp/journal/contents.html

資源タイプ	departmental bulletin paper
ISSN	0023-2513　OPACで所蔵を検索　 CiNiiで学外所蔵を検索
NCID	AA00711740　OPACで所蔵を検索　 CiNiiで表示

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