00422107

open access

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Impaired response of perforating arteries to hypercapnia in chronic hyperglycemia

English (英語)

The Kobe journal of the medical sciences

52(1/2)

27-35

Kobe University School of Medicine

2006-01

2007-01-15

Diabetes mellitus increases the risk of cerebrovascular disease, the effects ofhypercapnia on CBF (cerebral blood flow) and cerebrovascular reactivity duringdiabetes are still inconsistent. Here, we have established a new microangiographictechnique using synchrotron radiation (SPring-8, Japan), which enabled us to visualizerat cerebral vessels with high spatial resolution in real time. The goal of the studypresented here was to identify the effects of chronic hyperglycemia onhypercapnia-induced vascular responses (endothelium-dependent vasodilatation) andnitric oxide (NO) donor- induced vascular responses (endothelium-independent) ofperforating arteries and of the deeply located large cerebral arteries. We found asignificant vasodilatation of rat perforating arteries after hypercapnia with a maximumdiameter of approximately 140% of baseline in normal Wistar rats. Chronichyperglycemia impaired vasodilatation of perforating arteries in genetically diabeticGK rats. SNP (sodium nitroprusside) caused a similar vasodilatation of perforatingvessels in normal and chronic hyperglycemia, indicating that endothelium-dependentvasodilatation of perforating arteries may be specifically impaired in chronichyperglycemia. Possible impairment of endothelium-dependent vasodilatation inperforating vessels during chronic hyperglycemia may cause decreased vascularreserve capacity of perforating artery, resulting in the increased ischemic insults andcerebrovascular diseases in diabetes.

cerebral vessels

紀要論文