Proposed modification of the eighth edition of the AJCC-ypTNM staging system of esophageal squamous cell cancer treated with neoadjuvant chemotherapy: Unification of the AJCC staging system and the Japanese classification

Oshikiri, Taro; Goto, Hironobu; Kato, Takashi; Sawada, Ryuichiro; Harada, Hitoshi; Urakawa, Naoki; Hasegawa, Hiroshi; Kanaji, Shingo; Yamashita, Kimihiro; Matsuda, Takeru; Fujino, Yasuhiro; Tominaga, Masahiro; Kakeji, Yoshihiro

https://hdl.handle.net/20.500.14094/0100477399

このアイテムのアクセス数:915件（2026-04-03 14:02 集計）

閲覧可能ファイル

ファイル	フォーマット	サイズ	閲覧回数	説明
0100477399 (fulltext)	pdf	713 KB	174
Supplementary Table (dataset)	pdf	57.5 KB	64

メタデータ

ファイル出力

メタデータID	0100477399
アクセス権	open access
出版タイプ	Accepted Manuscript
タイトル	Proposed modification of the eighth edition of the AJCC-ypTNM staging system of esophageal squamous cell cancer treated with neoadjuvant chemotherapy: Unification of the AJCC staging system and the Japanese classification
著者	Oshikiri, Taro ; Goto, Hironobu ; Kato, Takashi ; Sawada, Ryuichiro ; Harada, Hitoshi ; Urakawa, Naoki ; Hasegawa, Hiroshi ; Kanaji, Shingo ; Yamashita, Kimihiro ; Matsuda, Takeru ; Fujino, Yasuhiro ; Tominaga, Masahiro ; Kakeji, Yoshihiro
著者ID A0849 研究者ID 1000030771498 KUID https://kuid-rm-web.ofc.kobe-u.ac.jp/search/detail?systemId=b9ef293e7421679f520e17560c007669 著者名 Oshikiri, Taro 押切, 太郎オシキリ, タロウ所属機関名医学研究科
著者ID A2963 KUID https://kuid-rm-web.ofc.kobe-u.ac.jp/search/detail?systemId=523a1152c71d5a7e520e17560c007669 著者名 Goto, Hironobu 後藤, 裕信ゴトウ, ヒロノブ所属機関名医学部附属病院
著者名 Kato, Takashi
著者ID A3029 KUID https://kuid-rm-web.ofc.kobe-u.ac.jp/search/detail?systemId=558951227bf17de4520e17560c007669 著者名 Sawada, Ryuichiro 澤田, 隆一郎サワダ, リュウイチロウ所属機関名医学部附属病院
著者ID A3023 KUID https://kuid-rm-web.ofc.kobe-u.ac.jp/search/detail?systemId=6890d97a51055143520e17560c007669 著者名 Harada, Hitoshi 原田, 仁ハラダ, ヒトシ所属機関名医学部附属病院
著者ID A2526 研究者ID 1000020647763 KUID https://kuid-rm-web.ofc.kobe-u.ac.jp/search/detail?systemId=cee872a7fac91c14520e17560c007669 著者名 Urakawa, Naoki 裏川, 直樹ウラカワ, ナオキ所属機関名医学部附属病院
著者ID A1558 研究者ID 1000050529542 KUID https://kuid-rm-web.ofc.kobe-u.ac.jp/search/detail?systemId=70d816578161532d520e17560c007669 著者名 Hasegawa, Hiroshi 長谷川, 寛ハセガワ, ヒロシ所属機関名医学部附属病院
著者ID A1519 研究者ID 1000010637052 KUID https://kuid-rm-web.ofc.kobe-u.ac.jp/search/detail?systemId=508b6461f962866e520e17560c007669 著者名 Kanaji, Shingo 金治, 新悟カナジ, シンゴ所属機関名医学部附属病院
著者ID A1436 研究者ID 1000080535427 KUID https://kuid-rm-web.ofc.kobe-u.ac.jp/search/detail?systemId=a1b771806c49baeb520e17560c007669 著者名 Yamashita, Kimihiro 山下, 公大ヤマシタ, キミヒロ所属機関名医学部附属病院
著者ID A1537 研究者ID 1000030782734 KUID https://kuid-rm-web.ofc.kobe-u.ac.jp/search/detail?systemId=fcf7c52c66d495fa520e17560c007669 著者名 Matsuda, Takeru 松田, 武マツダ, タケル所属機関名医学研究科
著者名 Fujino, Yasuhiro
著者名 Tominaga, Masahiro
著者ID A1706 研究者ID 1000080284488 KUID https://kuid-rm-web.ofc.kobe-u.ac.jp/search/detail?systemId=2901d33e92e00ca4520e17560c007669 著者名 Kakeji, Yoshihiro 掛地, 吉弘カケジ, ヨシヒロ所属機関名医学研究科
言語	English (英語)
収録物名	European Journal of Surgical Oncology
巻(号)	48(8)
ページ	1760-1767
出版者	Elsevier
刊行日	2022-08
公開日	2023-08-19
抄録	Background: The eighth edition of the American Joint Committee on Cancer (AJCC) tumor node metastasis (AJCC-TNM 8th) system adopted the newly separate post-neoadjuvant pathologic stage group (ypTNM). However, it is not compatible with the Japanese pathologic classification after neoadjuvant chemotherapy (JPN-CT-pTNM). The aim of this study is to clarify the subjects of the AJCC-ypTNM 8th and propose a unification of the AJCC and Japanese systems to create novel AJCC-CT-pTNM 8th. Methods: Participants were 304 esophageal squamous cell carcinoma (ESCC) patients who underwent neoadjuvant chemotherapy followed by 3 stage esophagectomy between 2010 and 2019. Predictive probabilities of pN, pM in AJCC-ypTNM 8th and JPN-CT-pTNM 11th systems were evaluated to propose novel system. Results: In training data from 234 patients, the overall survival rate was statistically better for ypStage IIIA than ypStage II (P = 0.040) resulting in staging inversion in AJCC-ypTNM 8th. Predictive probability of pathological N status in AJCC-ypTNM 8th (Akaike Information Criterion: AIC = 979.53) was superior to that in JPN-CT-pTNM 11th (AIC = 999.07). In AJCC-ypTNM 8th, 71% (15/21) of ypM1 diseases were supraclavicular lymph nodes (No. 104 L/N as regional in JPN-CT-pTNM 11th) metastases with considerably good prognosis. The predictive probability of the novel AJCC-CT-pTNM 8th [unification of ypStage II and IIIA, conversion of supraclavicular L/Ns metastases from ypM to ypN] (AIC = 1054.24) was superior to that of the existing AJCC-ypTNM 8th (AIC = 1070.74). The feasibility of novel system was validated using test data from 70 patients. Conclusions: Unification of the AJCC and Japanese systems yields a simpler and more precise predictive system after neoadjuvant chemotherapy.
キーワード	Esophageal squamous cell carcinoma (ESCC)
	American Joint committee on cancer (AJCC)
	Post-neoadjuvant tumor node metastasis (ypTNM) staging
	Japanese classification
	AJCC-CT-TNM 8th
カテゴリ	医学研究科
	医学部附属病院
	学術雑誌論文
権利	© 2022 Elsevier Ltd, BASO ~ The Association for Cancer Surgery, and the European Society of Surgical Oncology.
権利	This manuscript version is made available under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International license.
関連情報	DOI https://doi.org/10.1016/j.ejso.2022.01.014

資源タイプ	journal article
eISSN	0748-7983　OPACで所蔵を検索　 CiNiiで学外所蔵を検索

閲覧可能ファイル

メタデータ

詳細を表示