A genome-wide association study identifying single nucleotide polymorphisms in the PPFIBP2 gene was predictive for interstitial lung disease in rheumatoid arthritis patients

Hayashi, Shinya; Matsubara, Tsukasa; Fukuda, Koji; Maeda, Toshihisa; Funahashi, Keiko; Hashimoto, Marowa; Takashima, Yoshinori; Kikuchi, Kenichi; Fujita, Masahiro; Matsumoto, Tomoyuki; Kuroda, Ryosuke

https://hdl.handle.net/20.500.14094/0100477540

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メタデータID	0100477540
アクセス権	open access
出版タイプ	Version of Record
タイトル	A genome-wide association study identifying single nucleotide polymorphisms in the PPFIBP2 gene was predictive for interstitial lung disease in rheumatoid arthritis patients
著者	Hayashi, Shinya ; Matsubara, Tsukasa ; Fukuda, Koji ; Maeda, Toshihisa ; Funahashi, Keiko ; Hashimoto, Marowa ; Takashima, Yoshinori ; Kikuchi, Kenichi ; Fujita, Masahiro ; Matsumoto, Tomoyuki ; Kuroda, Ryosuke
著者ID A1470 研究者ID 1000020437487 KUID https://kuid-rm-web.ofc.kobe-u.ac.jp/search/detail?systemId=920f996ace595775520e17560c007669 著者名 Hayashi, Shinya 林, 申也ハヤシ, シンヤ所属機関名医学研究科
著者名 Matsubara, Tsukasa
著者名 Fukuda, Koji
著者ID A3018 研究者ID 1000010770084 ORCID 0000-0002-4078-3076 KUID https://kuid-rm-web.ofc.kobe-u.ac.jp/search/detail?systemId=91a26e4e94921ed6520e17560c007669 著者名 Maeda, Toshihisa 前田, 俊恒マエダ, トシヒサ所属機関名医学部附属病院
著者名 Funahashi, Keiko
著者名 Hashimoto, Marowa
著者名 Takashima, Yoshinori
著者名 Kikuchi, Kenichi
著者名 Fujita, Masahiro
著者ID A1443 研究者ID 1000050546588 KUID https://kuid-rm-web.ofc.kobe-u.ac.jp/search/detail?systemId=3b2197de7ea329b7520e17560c007669 著者名 Matsumoto, Tomoyuki 松本, 知之マツモト, トモユキ所属機関名医学研究科
著者ID A0783 研究者ID 1000080379362 KUID https://kuid-rm-web.ofc.kobe-u.ac.jp/search/detail?systemId=f51cbfc82378ae63520e17560c007669 著者名 Kuroda, Ryosuke 黒田, 良祐クロダ, リョウスケ所属機関名医学研究科
言語	English (英語)
収録物名	Rheumatology Advances in Practice
巻(号)	6(3)
ページ	rkac088
出版者	Oxford University Press (OUP)
刊行日	2022-10-29
公開日	2022-12-15
抄録	Objective Genetic polymorphisms might serve as useful prognostic markers for the timely diagnosis of RA. The purpose of this study was to identify genomic factors predictive of the occurrence of interstitial lung disease (ILD) in RA by performing a genome-wide association study of genetic variants, including single nucleotide polymorphisms (SNPs). Methods The study population included 306 RA patients. All patients were treated with conventional DMARDs, including 6–16 mg MTX per week. Clinical data and venous blood samples were collected from all patients before administration of DMARDs. A total of 278 347 SNPs were analysed to determine their association with ILD occurrence. Results Several SNPs were strongly associated with ILD occurrence (P < 10−5). rs6578890, which is located on chromosome 11 in the intronic region of the gene encoding tyrosine phosphatase receptor type F polypeptide-interacting protein-binding protein 2 (PPFIBP2), showed the strongest association with ILD occurrence (odds ratio 4.32, P = 10−7.93). Conclusion PPFIBP2 could be a useful genetic marker for occurrence of interstitial pneumonia in RA patients and might help to identify the risk of ILD occurrence before RA treatment, thereby improving patient outcomes.
キーワード	genome-wide screening
	RA
	interstitial lung disease
	single nucleotide polymorphisms
	PPFIBP2
カテゴリ	医学研究科
	医学部附属病院
	学術雑誌論文
権利	© The Author(s) 2022. Published by Oxford University Press on behalf of the British Society for Rheumatology.
権利	This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (https://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
関連情報	DOI https://doi.org/10.1093/rap/rkac088

資源タイプ	journal article
eISSN	2514-1775　OPACで所蔵を検索　 CiNiiで学外所蔵を検索

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