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https://hdl.handle.net/20.500.14094/0100477955
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2024-08-01
06:16 集計
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0100477955 (fulltext)
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メタデータID
0100477955
アクセス権
open access
出版タイプ
Version of Record
タイトル
Optogenetic Therapy for Visual Restoration
著者
Sakai, Daiki ; Tomita, Hiroshi ; Maeda, Akiko
著者名
Sakai, Daiki
著者名
Tomita, Hiroshi
著者名
Maeda, Akiko
言語
English (英語)
収録物名
International Journal of Molecular Sciences
巻(号)
23(23)
ページ
15041
出版者
MDPI
刊行日
2022-12
公開日
2022-12-26
抄録
Optogenetics is a recent breakthrough in neuroscience, and one of the most promising applications is the treatment of retinal degenerative diseases. Multiple clinical trials are currently ongoing, less than a decade after the first attempt at visual restoration using optogenetics. Optogenetic therapy has great value in providing hope for visual restoration in late-stage retinal degeneration, regardless of the genotype. This alternative gene therapy consists of multiple elements including the choice of target retinal cells, optogenetic tools, and gene delivery systems. Currently, there are various options for each element, all of which have been developed as a product of technological success. In particular, the performance of optogenetic tools in terms of light and wavelength sensitivity have been improved by engineering microbial opsins and applying human opsins. To provide better post-treatment vision, the optimal choice of optogenetic tools and effective gene delivery to retinal cells is necessary. In this review, we provide an overview of the advancements in optogenetic therapy for visual restoration, focusing on available options for optogenetic tools and gene delivery methods.
キーワード
optogenetics
gene therapy
retinitis pigmentosa
retina
retinal degeneration
retinal dystrophy
blindness
visual restoration
channelrhodopsin
opsin
カテゴリ
学術雑誌論文
権利
© 2022 by the authors. Licensee MDPI, Basel, Switzerland.
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
関連情報
DOI
https://doi.org/10.3390/ijms232315041
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資源タイプ
journal article
eISSN
1422-0067
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