0100479373

open access

Accepted Manuscript

Subtype Distribution and Drug Resistance Patterns Among HIV-1 Strains Prevalent in Makassar, Indonesia

English (英語)

AIDS Research and Human Retroviruses

39(3)

124-129

Mary Ann Liebert

2023-03

2023-03-15

Human immunodeficiency virus type 1 (HIV-1) is characterized by a large degree of genetic variability because of high rates of recombination and mutation, sizable population sizes, and rapid replication. Therefore, this study investigated HIV-1 subtype distribution and the appearance of drug resistance mutations (DRMs) in viruses that are prevalent in Makassar, South Sulawesi, Indonesia. The HIV-1 pol, env, and gag genes were amplified from 63 infected individuals and sequenced for a subtyping analysis. CRF01_AE was identified as the predominant HIV-1 circulating recombinant form (CRF) in Makassar, South Sulawesi, Indonesia. Subtype B and recombinant viruses containing CRF01_AE, CRF02_AG, and/or subtype B gene fragments were also detected. Several major DRMs against non-nucleoside reverse transcriptase inhibitors were found among antiretroviral therapy (ART)-experienced subjects, whereas ART-naive subjects did not possess any transmitted drug resistance. The prevalence of DRMs was very high among ART-experienced subjects; therefore, further surveillance is required in this region.

Indonesia

学術雑誌論文

This is the accepted version of the following article: [Subtype Distribution and Drug Resistance Patterns Among HIV-1 Strains Prevalent in Makassar, Indonesia. Siti Qamariyah Khairunisa, Ni Luh Ayu Megasari, Shuhei Ueda, Tomohiro Kotaki, Afif Nurul Hidayati, Nasronudin, and Masanori Kameoka. AIDS Research and Human Retroviruses 2023 39:3, 124-129], which has now been formally published in final form at AIDS Research and Human Retroviruses at https://doi.org/10.1089/aid.2022.0139. This original submission version of the article may be used for non-commercial purposes in accordance with the Mary Ann Liebert, Inc., publishers’ self-archiving terms and conditions.