Optical Coherence Tomography Fractional Flow Reserve and Cardiovascular Outcomes in Patients With Acute Coronary Syndrome

Kakizaki, Shunsuke; Otake, Hiromasa; Seike, Fumiyasu; Kawamori, Hiroyuki; Toba, Takayoshi; Nakano, Shinsuke; Tanimura, Kosuke; Takahashi, Yu; Fukuyama, Yusuke; Fujimoto, Daichi; Nakamura, Koichi; Fujii, Hiroyuki; Kozuki, Amane; Shite, Junya; Iwasaki, Masamichi; Takaya, Tomofumi; Yamaguchi, Osamu; Hirata, Ken-ichi

https://hdl.handle.net/20.500.14094/0100480882

このアイテムのアクセス数:104件（2025-06-30 14:47 集計）

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メタデータID	0100480882
アクセス権	open access
出版タイプ	Version of Record
タイトル	Optical Coherence Tomography Fractional Flow Reserve and Cardiovascular Outcomes in Patients With Acute Coronary Syndrome
著者	Kakizaki, Shunsuke ; Otake, Hiromasa ; Seike, Fumiyasu ; Kawamori, Hiroyuki ; Toba, Takayoshi ; Nakano, Shinsuke ; Tanimura, Kosuke ; Takahashi, Yu ; Fukuyama, Yusuke ; Fujimoto, Daichi ; Nakamura, Koichi ; Fujii, Hiroyuki ; Kozuki, Amane ; Shite, Junya ; Iwasaki, Masamichi ; Takaya, Tomofumi ; Yamaguchi, Osamu ; Hirata, Ken-ichi
著者名 Kakizaki, Shunsuke
著者ID A1446 研究者ID 1000060593803 KUID https://kuid-rm-web.ofc.kobe-u.ac.jp/search/detail?systemId=3716950f44dc6e72520e17560c007669 著者名 Otake, Hiromasa 大竹, 寛雅オオタケ, ヒロマサ所属機関名医学部附属病院
著者名 Seike, Fumiyasu
著者ID A2104 研究者ID 1000030801899 KUID https://kuid-rm-web.ofc.kobe-u.ac.jp/search/detail?systemId=79ca635343ef1815520e17560c007669 著者名 Kawamori, Hiroyuki 川森, 裕之カワモリ, ヒロユキ所属機関名医学部附属病院
著者ID A2536 研究者ID 1000030846770 KUID https://kuid-rm-web.ofc.kobe-u.ac.jp/search/detail?systemId=104f39bb341d5672520e17560c007669 著者名 Toba, Takayoshi 鳥羽, 敬義トバ, タカヨシ所属機関名医学部附属病院
著者名 Nakano, Shinsuke
著者名 Tanimura, Kosuke
著者名 Takahashi, Yu
著者名 Fukuyama, Yusuke
著者ID A3016 研究者ID 1000080792449 著者名 Fujimoto, Daichi 藤本, 大地フジモト, ダイチ所属機関名医学部附属病院
著者名 Nakamura, Koichi
著者名 Fujii, Hiroyuki
著者名 Kozuki, Amane
著者名 Shite, Junya
著者名 Iwasaki, Masamichi
著者名 Takaya, Tomofumi
著者名 Yamaguchi, Osamu
著者ID A0883 研究者ID 1000020283880 KUID https://kuid-rm-web.ofc.kobe-u.ac.jp/search/detail?systemId=383af6bc2b817735520e17560c007669 著者名 Hirata, Ken-ichi 平田, 健一ヒラタ, ケンイチ所属機関名医学研究科
言語	English (英語)
収録物名	JACC: Cardiovascular Interventions
巻(号)	15(20)
ページ	2035-2048
出版者	Elsevier
刊行日	2022-10-24
公開日	2023-03-22
抄録	Background Optical coherence tomography–derived fractional flow reserve (OCT-FFR) correlates strongly with wire-based FFR; however, its clinical significance remains uncertain. Objectives This study sought to investigate the relationship between post–percutaneous coronary intervention (PCI) OCT-FFR and long-term clinical outcomes in acute coronary syndrome (ACS). Methods This retrospective, multicenter, observational cohort study included consecutive patients with ACS who underwent OCT-guided emergency PCI. We analyzed post-PCI OCT images and calculated OCT-FFR to identify independent factors associated with target vessel failure (TVF) after PCI. Results Among 364 enrolled patients, 54 experienced TVF during a median follow-up of 36 (IQR: 26-48) months. Vessel-level OCT-FFR was significantly lower in the TVF group than in the non-TVF group (0.87 vs 0.94; P < 0.001). In the multivariable Cox regression analysis, low vessel-level OCT-FFR (HR per 0.1 increase: 0.38; 95% CI: 0.29-0.49; P < 0.001) and thin-cap fibroatheroma in the nonculprit lesion were independently associated with TVF. The TVF rate of vessels with both low vessel-level OCT-FFR (<0.90) and thin-cap fibroatheroma in the nonculprit lesion was 8.1 times higher than that of all other vessels (69.3% vs 12.4%; HR: 8.13; 95% CI: 4.33-15.25; log-rank P < 0.001). Furthermore, adding vessel-level OCT-FFR to baseline characteristics and post-PCI OCT findings improved discriminatory and reclassification ability in identifying patients with subsequent TVF. Conclusions Vessel-level OCT-FFR was an independent factor associated with TVF after PCI in patients with ACS. Adding the OCT-FFR measurement to post-PCI OCT findings may enable better discrimination of patients with subsequent TVF after PCI for ACS. (Relationship between Intracoronary Optical Coherence Tomography Derived Virtual Fractional Flow Reserve and cardiovascular outcome on Acute coronary syndrome; UMIN000043858)
キーワード	acute coronary syndrome
	fractional flow reserve
	optical coherence tomography
	percutaneous coronary intervention
	target vessel failure
カテゴリ	医学研究科
	医学部附属病院
	学術雑誌論文
権利	© 2022 The Authors. Published by Elsevier on behalf of the American College of Cardiology Foundation.
権利	Creative Commons Attribution 4.0 International
関連情報	DOI https://doi.org/10.1016/j.jcin.2022.08.010

資源タイプ	journal article
ISSN	1936-8798　OPACで所蔵を検索　 CiNiiで学外所蔵を検索
eISSN	1876-7605　OPACで所蔵を検索　 CiNiiで学外所蔵を検索

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