Multicenter study on atypical femoral fractures in patients with bone metastases taking bone- modifying agents

Fukui, Tomoaki; Oe, Keisuke; Kawamoto, Teruya; Morishita, Masayuki; Fujita, Ikuo; Takahara, Shunsuke; Yoshida, Keiji; Ito, Kenjiro; Shoda, Etsuo; Hiranaka, Takafumi; Tsunoda, Masaya; Kuroda, Ryosuke; Niikura, Takahiro

https://hdl.handle.net/20.500.14094/0100482795

このアイテムのアクセス数:67件（2025-05-31 10:14 集計）

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メタデータID	0100482795
アクセス権	open access
出版タイプ	Version of Record
タイトル	Multicenter study on atypical femoral fractures in patients with bone metastases taking bone- modifying agents
著者	Fukui, Tomoaki ; Oe, Keisuke ; Kawamoto, Teruya ; Morishita, Masayuki ; Fujita, Ikuo ; Takahara, Shunsuke ; Yoshida, Keiji ; Ito, Kenjiro ; Shoda, Etsuo ; Hiranaka, Takafumi ; Tsunoda, Masaya ; Kuroda, Ryosuke ; Niikura, Takahiro
著者ID A2565 研究者ID 1000050437688 ORCID 0000-0001-9795-9549 KUID https://kuid-rm-web.ofc.kobe-u.ac.jp/search/detail?systemId=e4d816863b4d40e0520e17560c007669 著者名 Fukui, Tomoaki 福井, 友章フクイ, トモアキ所属機関名医学部附属病院
著者ID A2091 研究者ID 1000020514623 ORCID 0000-0001-9992-4550 KUID https://kuid-rm-web.ofc.kobe-u.ac.jp/search/detail?systemId=346c887d8da368be520e17560c007669 著者名 Oe, Keisuke 大江, 啓介オオエ, ケイスケ所属機関名医学部附属病院
著者ID A1442 研究者ID 1000030420558 ORCID 0000-0003-1845-7482 著者名 Kawamoto, Teruya 河本, 旭哉カワモト, テルヤ所属機関名医学部附属病院
著者名 Morishita, Masayuki
著者名 Fujita, Ikuo
著者名 Takahara, Shunsuke
著者名 Yoshida, Keiji
著者名 Ito, Kenjiro
著者名 Shoda, Etsuo
著者名 Hiranaka, Takafumi
著者名 Tsunoda, Masaya
著者ID A0783 研究者ID 1000080379362 KUID https://kuid-rm-web.ofc.kobe-u.ac.jp/search/detail?systemId=f51cbfc82378ae63520e17560c007669 著者名 Kuroda, Ryosuke 黒田, 良祐クロダ, リョウスケ所属機関名医学部附属病院
著者ID A1418 研究者ID 1000040448171 著者名 Niikura, Takahiro 新倉, 隆宏ニイクラ, タカヒロ所属機関名医学研究科
言語	English (英語)
収録物名	Journal of Bone Oncology
巻(号)	40
ページ	100478
出版者	Elsevier
刊行日	2023-06
公開日	2023-08-17
抄録	Bone-modifying agents (BMAs), with bone-resorptive inhibitory effects, such as zoledronic acid and denosumab, are widely used at higher doses for bone-related events caused by bone metastasis of malignant tumors. These drugs have been suggested to be associated with atypical femoral fractures (AFFs), and the relationship between BMAs and AFFs has attracted attention. To investigate the clinical features including bone union time of AFFs in patients administered BMA for bone metastasis, we conducted a retrospective multicenter study. Thirty AFFs from 19 patients were enrolled in this study. Thirteen patients had bilateral AFFs, and nineteen AFFs had prodromal symptoms. Eighteen AFFs underwent surgery after complete fracture, three failed to achieve bone union and required nonunion surgery, and 11 AFFs that achieved bone union had an average period until bone union of 16.2 months, which was much longer than that previously reported for ordinary AFFs. Seven patients discontinued the BMAs, but not due to AFFs. Stopping BMAs in patients with bone metastasis would make it difficult to secure their performance of activities of daily living, and AFF with BMA administration might require a longer time for union. Therefore, it would be important to prevent incomplete AFF from becoming complete AFF via prophylactic internal fixation.
キーワード	Atypical femoral fracture
	Bone metastasis
	Zoledronic acid
	Bone-modifying agent
	Bisphosphonate
カテゴリ	医学研究科
	医学部附属病院
	学術雑誌論文
権利	© 2023 The Authors. Published by Elsevier GmbH.
権利	This is an open access article under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International license
関連情報	DOI https://doi.org/10.1016/j.jbo.2023.100478

資源タイプ	journal article
ISSN	2212-1366　OPACで所蔵を検索　 CiNiiで学外所蔵を検索
eISSN	2212-1374　OPACで所蔵を検索　 CiNiiで学外所蔵を検索

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