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https://hdl.handle.net/20.500.14094/0100482881
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2024-06-25
17:18 集計
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0100482881 (fulltext)
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メタデータID
0100482881
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open access
出版タイプ
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タイトル
Social circuits and their dysfunction in autism spectrum disorder
著者
Sato, Masaaki ; Nakai, Nobuhiro ; Fujima, Shuhei ; Choe, Y. Katrina ; Takumi, Tooru
著者名
Sato, Masaaki
著者ID
A2840
研究者ID
1000000808967
KUID
https://kuid-rm-web.ofc.kobe-u.ac.jp/search/detail?systemId=df101e8e31114511520e17560c007669
著者名
Nakai, Nobuhiro
中井, 信裕
ナカイ, ノブヒロ
所属機関名
医学研究科
著者名
Fujima, Shuhei
著者名
Choe, Y. Katrina
著者ID
A2484
研究者ID
1000000222092
KUID
https://kuid-rm-web.ofc.kobe-u.ac.jp/search/detail?systemId=8dd02eace7106104520e17560c007669
著者名
Takumi, Tooru
内匠, 透
タクミ, トオル
所属機関名
医学研究科
収録物名
Molecular Psychiatry
巻(号)
28(8)
ページ
3194-3206
出版者
Nature Publishing Group
刊行日
2023-08
公開日
2023-08-24
抄録
Social behaviors, how individuals act cooperatively and competitively with conspecifics, are widely seen across species. Rodents display various social behaviors, and many different behavioral paradigms have been used for investigating their neural circuit bases. Social behavior is highly vulnerable to brain network dysfunction caused by neurological and neuropsychiatric conditions such as autism spectrum disorders (ASDs). Studying mouse models of ASD provides a promising avenue toward elucidating mechanisms of abnormal social behavior and potential therapeutic targets for treatment. In this review, we outline recent progress and key findings on neural circuit mechanisms underlying social behavior, with particular emphasis on rodent studies that monitor and manipulate the activity of specific circuits using modern systems neuroscience approaches. Social behavior is mediated by a distributed brain-wide network among major cortical (e.g., medial prefrontal cortex (mPFC), anterior cingulate cortex, and insular cortex (IC)) and subcortical (e.g., nucleus accumbens, basolateral amygdala (BLA), and ventral tegmental area) structures, influenced by multiple neuromodulatory systems (e.g., oxytocin, dopamine, and serotonin). We particularly draw special attention to IC as a unique cortical area that mediates multisensory integration, encoding of ongoing social interaction, social decision-making, emotion, and empathy. Additionally, a synthesis of studies investigating ASD mouse models demonstrates that dysfunctions in mPFC-BLA circuitry and neuromodulation are prominent. Pharmacological rescues by local or systemic (e.g., oral) administration of various drugs have provided valuable clues for developing new therapeutic agents for ASD. Future efforts and technological advances will push forward the next frontiers in this field, such as the elucidation of brain-wide network activity and inter-brain neural dynamics during real and virtual social interactions, and the establishment of circuit-based therapy for disorders affecting social functions.
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医学研究科
学術雑誌論文
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© The Author(s) 2023
Creative Commons Attribution 4.0 International License
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資源タイプ
journal article
言語
Japanese (日本語)
ISSN
1359-4184
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eISSN
1476-5578
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関連情報
DOI
https://doi.org/10.1038/s41380-023-02201-0
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