神戸大学附属図書館デジタルアーカイブ
https://hdl.handle.net/20.500.14094/0100483312

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メタデータID
0100483312
アクセス権
open access
出版タイプ
Accepted Manuscript
タイトル
Effect of anticholinergics for the treatment of death rattle of cancer patients in the last days: a multicenter prospective cohort study
その他のタイトル
Anticholinergic drugs for death rattle in dying patients with cancer: multicentre prospective cohort study
著者
Yamaguchi, Takashi ; Yokomichi, Naosuke ; Yamaguchi, Takuhiro ; Maeda, Isseki ; Matsunuma, Ryo ; Tanaka-Yagi, Yukako ; Akatani, Asami ; Suzuki, Kozue ; Kohara, Hiroyuki ; Taniyama, Tomohiko ; Matsuda, Yosuke ; Nakajima, Nobuhisa ; Morita, Tatsuya ; Tsuneto, Satoru ; Mori, Masanori
著者ID
A1495
研究者ID
1000010725394
KUID
https://kuid-rm-web.ofc.kobe-u.ac.jp/search/detail?systemId=34000224acf4b046520e17560c007669
著者名
Yamaguchi, Takashi
山口, 崇
ヤマグチ, タカシ
所属機関名
医学部附属病院
著者名
Yokomichi, Naosuke
著者名
Yamaguchi, Takuhiro
著者名
Maeda, Isseki
著者名
Matsunuma, Ryo
著者名
Tanaka-Yagi, Yukako
著者ID
A3237
研究者ID
1000050806099
KUID
https://kuid-rm-web.ofc.kobe-u.ac.jp/search/detail?systemId=c410fde2aa2f2b52520e17560c007669
著者名
Akatani, Asami
赤谷, 麻美
アカタニ, アサミ
所属機関名
医学部附属病院
著者名
Suzuki, Kozue
著者名
Kohara, Hiroyuki
著者名
Taniyama, Tomohiko
著者名
Matsuda, Yosuke
著者名
Nakajima, Nobuhisa
著者名
Morita, Tatsuya
著者名
Tsuneto, Satoru
著者名
Mori, Masanori
言語
English (英語)
収録物名
BMJ Supportive & Palliative Care
巻(号)
13
ページ
462-471
出版者
British Medical Journal Publishing Group
刊行日
2023-12
公開日
2023-10-05
注記
Published Online: 2022-11-10
抄録
【Background】This study aimed to investigate the effectiveness of anticholinergics (AC) for death rattle in dying patients with cancer. 【Methods】 This is a prospective cohort study enrolled Terminally ill adult (20 years or older) patients with cancer who developed substantial death rattle (Back score ≥2) from 23 palliative care units in Japan. AC treatment for death rattle was prescribed according to primary physician’s decision. The primary outcome was the proportion of patients whose death rattle improved, which was defined as a Back score of ≤1. We compared the proportion of improved cases in patients treated with (AC group) and without (non-AC group) AC, controlling potential confounders by employing propensity score weighting. 【Results】 Of the 1896 patients enrolled, we included 196 who developed a substantial death rattle. Of these, 81 received AC. 56.8% in the AC group and 35.4% in the non-AC group had an improved death rattle at 8 hours after baseline. In the weighted analysis, AC group showed significant improvements in death rattle, with an adjusted OR of 4.47 (95% CI 2.04 to 9.78; p=0.0024). All sensitivity analyses achieved essentially the same results. In the subgroup analysis, ACs were strongly associated with death rattle improvement in men, patients with lung cancer, and type 1 death rattle (adjusted OR 5.81, 8.38 and 9.32, respectively). 【Conclusions】 In this propensity score-weighted analysis, ACs were associated with death rattle improvement in terminally ill patients with cancer who developed substantial death rattle.
キーワード
Death rattle
Anticholinergics
Palliative care
Cancer
カテゴリ
医学部附属病院
学術雑誌論文
権利
This article has been accepted for publication in [BMJ Supportive & Palliative Care, 2022] following peer review, and the Version of Record can be accessed online at http://dx.doi.org/10.1136/spcare-2022-003823.
© Authors (or their employer(s)) 2022. Reuse of this manuscript version (excluding any databases, tables, diagrams, photographs and other images or illustrative material included where a another copyright owner is identified) is permitted strictly pursuant to the terms of the Creative Commons Attribution-Non Commercial 4.0 International (CC-BY-NC 4.0) https://creativecommons.org/licenses/by-nc/4.0/
CC license
Creative Commons Attribution-Non Commercial 4.0 International
関連情報
DOI
https://doi.org/10.1136/spcare-2022-003823