0100485324

open access

Accepted Manuscript

Two pregnant women with immune-mediated thrombotic thrombocytopenic purpura: A case report

English (英語)

Journal of Obstetrics and Gynaecology Research

49(12)

2969-2974

John Wiley & Sons

2023-12

2024-09-18

Thrombotic thrombocytopenic purpura (TTP) during pregnancy is life-threatening. We encountered two pregnant women with immune-mediated TTP (iTTP). A 40-year-old primigravida woman was referred at 19 gestational weeks (GWs) owing to iTTP. She received plasma exchange (PE) and steroid therapies and delivered a live infant at 27 GWs by cesarean delivery. A 29-year-old primigravida woman was referred owing to intrauterine fetal death and thrombocytopenia at 20 GWs. She was diagnosed with iTTP and received PE therapy. She required additional PE and steroid therapies owing to relapse. Before her second pregnancy, she received prednisolone and hydroxychloroquine according to the therapy for systemic lupus erythematosus (SLE). She had induced labor at 37 GWs owing to decrease plasma level of a disintegrin-like and metalloproteinase with thrombospondin type 1 motif 13 (ADAMTS13) activity. Close monitoring of plasma ADAMTS13 activity level and treatments for underlying SLE may prevent iTTP relapse and lead to a good prognosis.

steroid

学術雑誌論文

This is the peer reviewed version of the following article: [Uchida, A, Tanimura, K, Sasagawa, Y, Yamada, H, Katayama, Y, Matsumoto, M. Two pregnant women with immune-mediated thrombotic thrombocytopenic purpura: A case report. J Obstet Gynaecol Res. 2023; 49(12): 2969–2974.], which has been published in final form at [https://doi.org/10.1111/jog.15793]. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. This article may not be enhanced, enriched or otherwise transformed into a derivative work, without express permission from Wiley or by statutory rights under applicable legislation. Copyright notices must not be removed, obscured or modified. The article must be linked to Wiley’s version of record on Wiley Online Library and any embedding, framing or otherwise making available the article or pages thereof by third parties from platforms, services and websites other than Wiley Online Library must be prohibited.