Gold Nanoparticles Enhance the Tumor Growth-Suppressing Effects of Cetuximab and Radiotherapy in Head and Neck Cancer In Vitro and In Vivo

Sato, Takumi; Kakei, Yasumasa; Hasegawa, Takumi; Kashin, Masahiko; Teraoka, Shun; Yamaguchi, Akinobu; Sasaki, Ryohei; Akashi, Masaya

https://hdl.handle.net/20.500.14094/0100485463

このアイテムのアクセス数:69件（2025-06-17 14:42 集計）

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メタデータID	0100485463
アクセス権	open access
出版タイプ	Version of Record
タイトル	Gold Nanoparticles Enhance the Tumor Growth-Suppressing Effects of Cetuximab and Radiotherapy in Head and Neck Cancer In Vitro and In Vivo
著者	Sato, Takumi ; Kakei, Yasumasa ; Hasegawa, Takumi ; Kashin, Masahiko ; Teraoka, Shun ; Yamaguchi, Akinobu ; Sasaki, Ryohei ; Akashi, Masaya
著者名 Sato, Takumi
著者ID A2217 研究者ID 1000070772896 ORCID 0000-0002-5997-514X KUID https://kuid-rm-web.ofc.kobe-u.ac.jp/search/detail?systemId=3e2a39a5f4448ccc520e17560c007669 著者名 Kakei, Yasumasa 筧, 康正カケイ, ヤスマサ所属機関名医学部附属病院
著者ID A1489 研究者ID 1000050546497 KUID https://kuid-rm-web.ofc.kobe-u.ac.jp/search/detail?systemId=322ffbb7f3848e30520e17560c007669 著者名 Hasegawa, Takumi 長谷川, 巧実ハセガワ, タクミ所属機関名医学研究科
著者名 Kashin, Masahiko
著者名 Teraoka, Shun
著者名 Yamaguchi, Akinobu
著者ID A1363 研究者ID 1000030346267 KUID https://kuid-rm-web.ofc.kobe-u.ac.jp/search/detail?systemId=f5e9afd9968a7ac8520e17560c007669 著者名 Sasaki, Ryohei 佐々木, 良平ササキ, リョウヘイ所属機関名医学部附属病院
著者ID A1492 研究者ID 1000040597168 KUID https://kuid-rm-web.ofc.kobe-u.ac.jp/search/detail?systemId=b7649a2950dc725a520e17560c007669 著者名 Akashi, Masaya 明石, 昌也アカシ, マサヤ所属機関名医学研究科
言語	English (英語)
収録物名	Cancers
巻(号)	15(23)
ページ	5697
出版者	MDPI
刊行日	2023-12
公開日	2023-12-18
抄録	Introduction: Head and neck squamous cell carcinoma (HNSCC) treatment includes surgery, radiotherapy, and immunotherapy with the aim of eradicating cancer cells without affecting normal tissues. HNSCC expresses epidermal growth factor receptor (EGFR) and cetuximab, an IgG1 monoclonal antibody targeting epidermal growth factor receptor, has been approved for the treatment of HNSCC. However, cetuximab has low reactivity and induces serious side effects. Gold nanoparticles (AuNPs) were reported to enhance the local antitumor effects of radiotherapy without damaging normal cells. Methods and Results: This study investigated the in vitro effects of single and combination therapy with AuNPs (1.0 nM), cetuximab (30 nM), and radiotherapy (4 Gy) on a human HNSCC cell line, HSC-3. Combination treatment of AuNPs + cetuximab + radiotherapy markedly reduced HSC-3 numbers and proliferation and enhanced apoptosis compared with single and double combination treatments. Furthermore, the in vivo combination treatment (AuNPs + cetuximab + radiotherapy) of a xenograft model of HSC-3 cells transplanted into nude mice (BALB/cAJcl-nu/nu) reduced the tumor volume compared with the controls. Scanning electron microscopy demonstrated the presence of AuNPs in tumor tissues and toxicity analysis indicated that AuNPs had no toxic effect on normal tissues. Conclusions: This study showed that AuNPs alone do not have a tumor-suppressing effect, but they sensitize tumors to radiotherapy and bind to cetuximab, leading to enhanced antitumor effects.
キーワード	oral squamous cell carcinoma
	irradiation
	cetuximab
	gold nanoparticle
カテゴリ	医学研究科
	医学部附属病院
	学術雑誌論文
権利	© 2023 by the authors. Licensee MDPI, Basel, Switzerland.
権利	This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license
関連情報	DOI https://doi.org/10.3390/cancers15235697

資源タイプ	journal article
eISSN	2072-6694　OPACで所蔵を検索　 CiNiiで学外所蔵を検索

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