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EFFECT OF VITAMIN E ON THE RESPONSE OF LUNG ANTIOXIDANT ENZYMES IN YOUNG RATS EXPOSED TO HYPEROXIA

English (英語)

The Kobe journal of the medical sciences

33(2)

53-63

1987-04

The effects of vitamin E on the lung hyperoxic injury were investigated by the response of lung antioxidant enzymes in young weanling rats exposed to 95% oxygen. The body weight in hyperoxic rats decreased in the period from 48 to 96 hours of oxygen exposure and it was significantly lower than that of rats under room air at 48 hours or more of oxygen exposure. The administration of vitamin E 15 mg/100g of body weight showed no effect on weight gain. The plasma lipoperoxide level elevated in rats exposed to hyperoxia for 7 days, and the increase was inhibited by the administration of vitamin E. Lung antioxidant enzymes, superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px), were significantly induced in rats exposed to hyperoxia for 3 days and 7 days; however, the catalase activity was not affected by oxygen exposure. The elevation of SOD activity in the lung exposed to hyperoxia was inhibited by the administration of vitamin E. These findings suggest that the initial response in the antioxidant defense system of lungs against hyperoxia is conducted by the antioxidant enzymes, particularly SOD and GSH-Px; and vitamin E plays a potential role in the defense against the exposure to highly concentrated oxygen.

bronchopulmonary dysplasia

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