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EFFECTS OF COADMINISTERED ANTIEPILEPTIC DRUGS ON FREE FRACTIONS OF PHENOBARBITAL AND VALPROIC ACID IN EPILEPTIC CHILDREN

English (英語)

The Kobe journal of the medical sciences

32(5)

141-149

1986-10

The free fractions of phenobarbital and valproic acid were determined in 198 epileptic children. The total and free phenobarbital concentrations were 15.83 ± 5.59 μg/ml and 8.27 ± 2.81 μg/ml in PB monopharmacy, while those in PB polypharmacy with five drugs were 39. 73 ± 14.41 μg/ml and 21 ± 6.61 μg/ml, respectively. The free fraction of phenobarbital was 51.32 ± 3.92% in PB monopharmacy, while that in PB polypharmacy with five drugs was 54 ± 2.94%. The serum albumin concentrations were 4.43 ± 0.21 g/dl in PB monopharmacy and 4.10 ± 0.28 g/dl in PB polypharmacy with five drugs. The total, free valproic acid concentration and free fraction were 95.66 ± 28.57 μg/ml, 11.75 ±7.95 μg/ml and 11.28 ± 3.93% in VPA monopharmacy, while those in VPA polypharmacy with three drugs were 80.31 ± 22.93 μg/ml, 7.47 ± 2.43 μg/ml and 9.19 ± 1.30%. The serum albumin concentrations were 4.38 ± 0.26 g/ml in VPA monopharmacy, and 3.87 ± 0.05 g/dl in VPA polypharmacy with five drugs. The serum albumin concnetration significantly decreased with number of coadministered drugs in PB polypharmacy and VPA polypharmacy.

serum albumin

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