0100488753

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CHROMOSOME ABERRATIONS INDUCED BY 7,12-DIMETHYLBENZ(A)ANTHRACENE IN RAT BONE MARROW CELLS : THEIR RELATIONSHIP TO CHROMOSOME BANDS AND THE INFLUENCE OF ERYTHROPOIETIN

English (英語)

The Kobe journal of the medical sciences

31(1)

1-17

1985-02

The distribution of chromosomal aberrations (CA) along all chromosomes was studied in bone marrow cells of rats treated with 7 ,12-dimethylbenz(a)anthracene (DMBA) using the Q-banding technique. With respect to chromosomal localization, the largest telocentric chromosome (#2) was most susceptible to DMBA. The distribution of CA on chromosomal bands was non-random and the bands 1q22, 2q16, 2q22, 2q24, 3q24, 4q22, 4q34, 5q12, 6q24, 11q12, and 14q11 were involved in CA at a statistically significant level. Most of them were Q-negative bands and some Q-positive bands and interfaces were also involved. Comparison with the results obtained by the direct measurement method suggested that mapping along banded chromosomes caused false results probably because many CA occurring in Q-bands or interbands may be read as occurring in Q-negative bands. An important role of growth stimuli such as erythropoietic stimuli in non-random distribution of CA in certain chromosomal bands in bone marrow cells was also demonstrated.

hormone

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