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HEPATOBILIARY SCINTIGRAPHY AND FUNCTION TEST WITH 99MTC-N-PYRIDOXYL-5-METHYLTRYPTOPHAN (99MTC-PMT)

English (英語)

The Kobe journal of the medical sciences

31(2)

85-94

1985-04

The authors studied the effectiveness of 99mTc-N-pyridoxyl-5-methyltryptophan (99mTc-PMT) for dynamic imaging and function on 40 patients with various hepatobiliary diseases and on healthy individuals. In healthy subjects, 99mTc-PMT is rapidly removed from the blood by the parenchymal cells of the liver and is excreted through the biliary system. The imaging of the liver, bile ducts, gallbladder and intestines with 99mTc-PMT was satisfactory. There was no renal visualization. In the case of serial images of healthy individuals, the gallbladder, intrahepatic bile duct and small intestine were visualized after 18.8 ± 7.2, 8.8 ± 1.4, and 16.7 ± 6.3 min, respectively; the mean peak time on the hepatogram was 8.0 ± 5.3 min. The bile ducts of patients with liver disorders were visualized later than those of healthy individuals. Particularly in the case of severe liver parenchymal diseases, the appearance time for the bile duct was significantly delayed. However, the delays in appearance time did not correlate well with low scores on the liver function test. At 70 min after the intravenous administration of 99mTc-PMT, 2.5 ± 1.5% of the injected dose was excreted into the urine of the healthy individuals. The urinary excretion of 99mTc-PMT by the patients with hepatobiliary diseases showed no increase, and it was not entirely related to the results of the serum function tests. However, a larger amount of 99mTc-PMT was retained in the blood of the patients with hepatobiliary diseases. The blood retention values at 20 min after injection into those with liver cirrhosis and hepatoma were significantly delayed.

liver function

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