神戸大学附属図書館デジタルアーカイブ
https://hdl.handle.net/20.500.14094/0100488856

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26-1_33-45 (fulltext) pdf 2.03 MB 82

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メタデータID
0100488856
アクセス権
open access
出版タイプ
Version of Record
タイトル
EFFECT OF A POTENT THROMBIN INHIBITOR, NO.407, ON NOVEL EXPERIMENTAL THROMBOSIS GENERATED BY ACETIC ACID
著者
IKOMA, Hidenobu ; OHTSU, Kunimiki ; TAMAO, Yoshikuni ; KIKUMOTO, Ryoji ; MORI, Etsuko ; FUNAHARA, Yoshinori ; OKAMOTO, Shosuke
著者名
IKOMA, Hidenobu
著者名
OHTSU, Kunimiki
著者名
TAMAO, Yoshikuni
著者名
KIKUMOTO, Ryoji
著者名
MORI, Etsuko
著者名
FUNAHARA, Yoshinori
著者名
OKAMOTO, Shosuke
言語
English (英語)
収録物名
The Kobe journal of the medical sciences
巻(号)
26(1)
ページ
33-45
刊行日
1980-03
抄録
By means of injuring the vessel wall with acetic acid, which has strong penetration and stimulation to tissue, we developed a novel animal model of the arterial thrombosis as indicated below, and investigated the antithrombotic effect of No. 407 in vivo by this model. The exposed carotid artery of rabbit anesthetized by pentobarbital was surrounded with absorbent cotton in a capsule, and then absorbent cotton was soaked sufficiently with acetic acid. Three hours after soak, the arterial segment was cut out, and the degree of the thrombus generation was observed under microscope. The optimal concentration of acetic acid for the thrombus generation under the treatment time of 3 hours was 90%. It was found that the thrombus generated by such method was the "white thrombus" at low magnification, and under the observation by scanning electron microscope, this thrombus was almost composed of aggregated platelets with entrapped erythrocytes and leukocytes. No. 407 administered intravenously and via continuous infusion prevented significantly the thrombus generation.
キーワード
synthetic thrombin-inhibitor
arginine derivative
animal model
thrombosis
acetic acid
カテゴリ
The Kobe journal of the medical sciences ＞ 26巻 ＞ 26巻1号（1980-03）
紀要論文