SUPPRESSION OF INSULIN RELEASE BY CALCIUM ANTAGONIST IN HUMAN INSULINOMA IN VIVO AND IN VITRO : Its Possible Role for Clinical Use

https://hdl.handle.net/20.500.14094/0100488892

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ファイル	フォーマット	サイズ	閲覧回数	説明
25-4_237-247 (fulltext)	pdf	429 KB	34

メタデータID	0100488892
アクセス権	open access
出版タイプ	Version of Record
タイトル	SUPPRESSION OF INSULIN RELEASE BY CALCIUM ANTAGONIST IN HUMAN INSULINOMA IN VIVO AND IN VITRO : Its Possible Role for Clinical Use
著者	著者名 MURAKAMI, Keiji
言語	English (英語)
収録物名	The Kobe journal of the medical sciences
巻(号)	25(4)
ページ	237-247
刊行日	1979-12
抄録	Intravenous infusion of diltiazem hydrochloride, calcium-antagonist, was performed on a 46-year-old woman with leucine-sensitive insulinoma which was beta cell adenoma histologically. It prevented the leucine-induced insulin secretion and hypoglycemic attacks effectively, although hypoglycemia persisted. Besides, oral administration of this agent lessened the hypoglycemic attacks. The inhibition of insulin release by the compound was demonstrated also in in vitro studies of incubation using the tumor tissues excised. These observations suggest the view that calcium-antagonist would be a useful agent to prevent the hypersecretion of hormones induced by functioning endocrine tumors.
キーワード	insulinoma
	insulin
	calcium-antagonist
	hypoglycemia
カテゴリ	The Kobe journal of the medical sciences ＞ 25巻＞ 25巻4号（1979-12）
カテゴリ	紀要論文

資源タイプ	departmental bulletin paper
ISSN	0023-2513　OPACで所蔵を検索　 CiNiiで学外所蔵を検索
NCID	AA00711740　OPACで所蔵を検索　 CiNiiで表示