0100489003

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EFFECT OF SYNTHETIC THYROTROPIN-RELEASING FACTOR ( TRF ) ON PITUITARY TSH SECRETION IN MAN, WITH SPECIAL REFERENCE TO THE EVALUATION FOR TRF TEST

English (英語)

The Kobe journal of the medical sciences

18(4)

215-228

1972-12

It is valuable to use synthetic thyrotropin-releasing factor for diagnosis and treatment of hypothalamic-pituitary disorders because of the specific action on TSH release induced by synthetic TRF from the anterior pituitary gland. We investigated about the standardization of "TRF test". TRF was administered in one of the four ways including, (i) a single intravenous injection of 25-1,000 μg, (ii) intravenous infusion over a period of 30 min to 8 hr, (iii) subcutaneous injection of 100-200 μg or, (iv) single oral dose of 1 - 10 mg. It is recommended to use the single intravenous injection as a routine TRF test because of the easiness of administration and the reliability of TRF absorption. Six different doses between 25 and 800 μg of TRF were administered to 40 normal subjects. The mean maximal rises in plasma TSH showed a dose-related response which was linear for the log of the dose in the range of 50 μg to 400 μg. In utilizing TRF as a test for pituitary thyrotropin reserve, we are currently giving doses of TRF at the extremes of the linear portion of the dose response curve which produced clear but significantly different elevation of plasma TSH ; a person who failed to respond at 50 μg of TRF was administered 400 μg of TRF one week later. Although intravenous single injection was employed as a screening test for TSH secretion, based upon the results mentioned above, the mode and dose of TRF administration and the pretreatment should be studied further for a more precise method of pituitary TSH reserve.

TSH

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