0100489030

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NEUROENDOCRINE CONTROL OF THE PITUITARY TSH SECRETION : II. Role and Mode of Pituitary TSH Secretion in the Cold

English (英語)

The Kobe journal of the medical sciences

16(3)

87-94

1970-09

In order to investigate the role and mode of pituitary thyrotropin in the early thyroid response to cold exposure, the contents of TSH in rat plasma and anterior pituitary were determined by means of TSH assay after Mckenzie's modification. Only in the case of rats acclimatized to 28°C a plasma TSH increase was observed by the exposure to 0°C, indicating that the temperature of acclimatization and cold exposure is essential for plasma TSH response. Pituitary TSH contents were decreased coincidentally with the variation of plasma TSH increase, suggesting that the TSH release was evoked by thyrotropin releasing facter (TRF). The elevation of plasma TSH was inhibited by the pretreatment with thyroid hormone and large dose of atropine, whereas pentobarbitulate did not inhibit the plasma TSH increase.

Thyrotropin Releasing Factor (TRF)

紀要論文