0100489089

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ELECTRON MICROSCOPIC STUDIES ON THE MATURATION PROCESS OF NEUTROPHILIC LEUKOCYTES

English (英語)

The Kobe journal of the medical sciences

13(1)

47-66

1967-03

Electron microscope was used to study the ultrastructure of neutrophilic leukocytes obtained from normal human bone marrow and peripheral blood of ten patients with acute myelocytic leukemia, The purpose of this report is to clarify the ultrastructure of maturation process of neutrophilic leukocytes and the forming mechanism of their specific granules. Appearance and increase of specific granules coincided with the development of endoplasmic reticulum and Golgi apparatus. They were found first adjacent to Golgi apparatus and later became to scatter and distribute widely throughout cytoplasm. By the above findings, it was concluded that specific granules were derived from Golgi apparatus, just same as lysosomes were produced by Golgi apparatus. Leukemic myeloblasts could be differentiated from myeloblasts of normal human bone marrow by morphological characteristics such as, atypical configuration of nuclei, increased numbers of mitochondria and clustered ribosomes in the cytoplasm. The findings represented preparatory arrangements for enormous multiplication of cells.

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