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https://hdl.handle.net/20.500.14094/0100490885

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メタデータID
0100490885
アクセス権
open access
出版タイプ
Accepted Manuscript
タイトル
Effectiveness of remimazolam in preventing postoperative delirium in elderly patients with proximal femoral fractures
著者
Fujimoto, Daichi ; Obata, Norihiko ; Mizobuchi, Satoshi
著者ID
A3016
研究者ID
1000080792449
著者名
Fujimoto, Daichi
藤本, 大地
フジモト, ダイチ
所属機関名
医学部附属病院
著者ID
A1649
研究者ID
1000030509443
KUID
https://kuid-rm-web.ofc.kobe-u.ac.jp/search/detail.html?systemId=3a3781350d7a72d5520e17560c007669
著者名
Obata, Norihiko
小幡, 典彦
オバタ, ノリヒコ
所属機関名
医学部附属病院
著者ID
A1643
研究者ID
1000070311800
KUID
https://kuid-rm-web.ofc.kobe-u.ac.jp/search/detail.html?systemId=537caea533819e60520e17560c007669
著者名
Mizobuchi, Satoshi
溝渕, 知司
ミゾブチ, サトシ
所属機関名
医学研究科
言語
English (英語)
収録物名
Journal of Anesthesia
巻(号)
38(4)
ページ
475-482
出版者
Springer Nature
刊行日
2024-08
公開日
2025-03-26
注記
Published Online: 26 March 2024
抄録
Purpose: Elderly patients with proximal femoral fractures are known to be a high-risk group for postoperative delirium (POD). The aim of this study was to determine the association of the benzodiazepine drug remimazolam with POD in elderly patients with proximal femoral fractures. Methods: In this single-center retrospective observational study, we included patients aged 65 years or older who underwent general anesthesia for proximal femoral fractures. We collected data for the incidence of POD within 3 days after surgery. We also obtained data for complications, preoperative blood examinations, maintenance anesthetic and intraoperative vital data. The occurrence of POD in patients who received remimazolam for general anesthesia (remimazolam group) was compared to that in patients who received general anesthesia with other anesthetic agents (other group). We finally conducted a multivariate analysis to assess the independent association of remimazolam with the risk of POD. Results: A total of 230 patients, including 54 patients who received remimazolam for maintenance anesthesia, were included in this study. The incidence of POD in the patients was 26.1%. The incidence of delirium within 3 days after surgery was significantly lower in the remimazolam group than in the other group (14.8% vs. 29.5%, p  =  0.03). The multivariate analysis showed that the use of remimazolam independently reduced the occurrence of POD (adjusted odds ratio  =  0.42, p  =  0.04). Conclusion: This retrospective observational study showed that the use of remimazolam is independently associated with a reduced incidence of POD. Remimazolam may be considered as an option to reduce POD in elderly patients with proximal femoral fractures.
キーワード
Remimazolam
Postoperative delirium
Elderly
Orthopedic surgery
Proximal femur fractures
カテゴリ
医学研究科
医学部附属病院
学術雑誌論文
権利
This version of the article has been accepted for publication, after peer review (when applicable) and is subject to Springer Nature's AM terms of use, but is not the Version of Record and does not reflect post-acceptance improvements, or any corrections. The Version of Record is available online at: https://doi.org/10.1007/s00540-024-03339-z
関連情報
DOI
https://doi.org/10.1007/s00540-024-03339-z
PMID
38530454