0100491871

open access

Accepted Manuscript

Cholelithiasis prevalence and risk factors in individuals with severe or profound intellectual and motor disabilities

English (英語)

Journal of Intellectual Disability Research

68(4)

317-324

John Wiley & Sons

2024-01-06

2025-01-06

【Background】 The prevalence and risk factors of cholelithiasis in individuals with severe or profound intellectual and motor disabilities (SPIMD) are poorly characterised. Thus, we aimed to investigate the prevalence and risk determinants of cholelithiasis in a cohort with SPIMD under medical care in a residential facility. 【Methods】 We categorised 84 patients in a residential hospital for persons with SPIMD into groups: those with (Group CL) and without (Group N) cholelithiasis. Gallstones were detected via computed tomography, ultrasonography or both. We evaluated gastrostomy status, nutritional and respiratory support, constipation, and bladder and kidney stones. Data were significantly analysed using univariate and multivariate logistic regression analyses. 【Results】 The prevalence rate of cholelithiasis in our SPIMD cohort was 27%. There were no significant differences in sex, age, weight, height, or Gross Motor Function Classification System between the two groups. However, more patients received enteral nutrition (39.13% vs. 6.56%; P = 0.000751) and were on ventilator support (56.52% vs. 19.67%; P = 0.00249) in Group CL than in Group N. Enteral nutrition [odds ratio (OR) 10.4, 95% confidence interval (CI) 1.98–54.7] and ventilator support (OR 20.0, 95% CI 1.99–201.0) were identified as independent risk factors for the prevalence of cholelithiasis in patients with SPIMD. 【Conclusions】 Patients with SPIMD demonstrated an increased prevalence of cholelithiasis, with a notable association between nutritional tonic use and respiratory support. Therefore, to emphasise the need for proactive screening, it is crucial to devise diagnostic and therapeutic strategies specific to patients with SPIMD. Further investigation is essential to validate our findings and explore causative factors.

severe or profound intellectual and motor disabilities

学術雑誌論文

This is the peer reviewed version of the following article: Watanabe, A., Tomioka, Y., Okata, Y., Yoshimura, S., Kumode, S., Iwabuchi, S., Kameoka, Y., Takanarita, Y., Uemura, K., Samejima, Y., Kawasaki, Y., and Bitoh, Y. (2024) Cholelithiasis prevalence and risk factors in individuals with severe or profound intellectual and motor disabilities. Journal of Intellectual Disability Research, 68: 317–324, which has been published in final form at https://doi.org/10.1111/jir.13113. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. This article may not be enhanced, enriched or otherwise transformed into a derivative work, without express permission from Wiley or by statutory rights under applicable legislation. Copyright notices must not be removed, obscured or modified. The article must be linked to Wiley’s version of record on Wiley Online Library and any embedding, framing or otherwise making available the article or pages thereof by third parties from platforms, services and websites other than Wiley Online Library must be prohibited.