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https://hdl.handle.net/20.500.14094/0100493304

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メタデータID
0100493304
アクセス権
open access
出版タイプ
Version of Record
タイトル
Effects of intermittently scanned continuous glucose monitoring on body weight and glycemic variability in individuals with overweight and impaired glucose tolerance or mild diabetes: A pilot randomized controlled trial
著者
Nishikage, Seiji ; Nakagawa, Yasushi ; Hirota, Yushi ; Yoshimura, Kai ; Ueda, Mariko ; Yamamoto, Akane ; Takayoshi, Tomofumi ; Matsuoka, Atsuko ; Takahashi, Michiko ; Takeda, Akihiko ; Yokota, Kazuki ; Nakamura, Tomoaki ; Sakaguchi, Kazuhiko ; Ogawa, Wataru
著者名
Nishikage, Seiji
著者名
Nakagawa, Yasushi
著者ID
A1420
研究者ID
1000080566018
KUID
https://kuid-rm-web.ofc.kobe-u.ac.jp/search/detail.html?systemId=8d8b694f29475700520e17560c007669
著者名
Hirota, Yushi
廣田, 勇士
ヒロタ, ユウシ
所属機関名
医学研究科
著者名
Yoshimura, Kai
著者名
Ueda, Mariko
著者名
Yamamoto, Akane
著者名
Takayoshi, Tomofumi
著者名
Matsuoka, Atsuko
著者ID
A1483
研究者ID
1000070570274
KUID
https://kuid-rm-web.ofc.kobe-u.ac.jp/search/detail.html?systemId=2792ef5b57661b4c520e17560c007669
著者名
Takahashi, Michiko
高橋, 路子
タカハシ, ミチコ
所属機関名
医学部附属病院
著者名
Takeda, Akihiko
著者名
Yokota, Kazuki
著者名
Nakamura, Tomoaki
著者ID
A1387
研究者ID
1000020444573
KUID
https://kuid-rm-web.ofc.kobe-u.ac.jp/search/detail.html?systemId=cc9462ee69a7a403520e17560c007669
著者名
Sakaguchi, Kazuhiko
坂口, 一彦
サカグチ, カズヒコ
所属機関名
医学研究科
著者ID
A1358
研究者ID
1000040294219
KUID
https://kuid-rm-web.ofc.kobe-u.ac.jp/search/detail.html?systemId=38228987a3a438c8520e17560c007669
著者名
Ogawa, Wataru
小川, 渉
オガワ, ワタル
所属機関名
医学研究科
言語
English (英語)
収録物名
Obesity Research & Clinical Practice
巻(号)
19(1)
ページ
70-76
出版者
Elsevier
刊行日
2025-01
公開日
2025-03-04
抄録
Objective: To investigate the effect of visualizing blood glucose variability by intermittently scanned continuous glucose monitoring (isCGM) on weight reduction in overweight individuals with impaired glucose tolerance (IGT) or mild type 2 diabetes mellitus (T2DM). Materials and methods: Forty overweight (BMI, ≥25 kg/m2) individuals with IGT or T2DM (drug naïve; HbA1c, ≤7.0 %) were included in this 24-week randomized controlled trial. Participants were randomly assigned to the control group (diet and exercise therapy) or the isCGM group (diet and exercise therapy plus isCGM). The primary endpoint was the change in body weight during the 24-week intervention period. Results: One participant in the isCGM group withdrew consent. We therefore analyzed 19 individuals in the isCGM group and 20 in the control group. Baseline BMI was significantly higher in the isCGM group (35.2 ± 5.7 kg/m²) compared to the control group (31.6 ± 6.8 kg/m²). Weight change in the isCGM and control groups (–1.8 and –2.2 kg) did not differ. However, the change in coefficient of variation (–0.9 and 2.9 %) of sensor glucose differed significantly between the two groups. isCGM scan frequency was positively correlated with time above range (TAR) during the first month, positively correlated with the change in protein intake, and negatively correlated with that in TAR. Conclusion: While isCGM use in overweight individuals with IGT or mild T2DM did not reduce body weight, it might have influence dietary behavior. The negative correlation between scan frequency and TAR, and the positive correlation between scan frequency and protein intake suggest that self-awareness of glucose fluctuations contributed to behavioral change.
キーワード
Intermittently scanned continuous glucose monitoring
Randomized controlled trial
Glycemic variability
Overweight individuals
Weight reduction
Self-monitoring
カテゴリ
医学研究科
医学部附属病院
学術雑誌論文
権利
© 2025 The Author(s). Published by Elsevier Ltd on behalf of Asia Oceania Association for the Study of Obesity.
CC license
This is an open access article under the Creative Commons Attribution 4.0 International license
関連情報
DOI
https://doi.org/10.1016/j.orcp.2025.01.008
PMID
39884899