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https://hdl.handle.net/20.500.14094/0100495828

このアイテムのアクセス数:13件（2025-05-12 12:45 集計）

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Supplementary material (dataset) pdf 1.62 MB 5

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メタデータID
0100495828
アクセス権
open access
出版タイプ
Version of Record
タイトル
Effect of the neonicotinoid pesticide clothianidin at a no-observed-adverse-effect-level (NOAEL) dose on maternal behavior in pregnant mice and their female offspring
著者
Nunobiki, Sarika ; Yoshimoto, Ayano ; Ito, Makiko ; Yonoichi, Sakura ; Hara, Yukako ; Ishida, Yuya ; Morishita, Rinako ; Mantani, Youhei ; Yokoyama, Toshifumi ; Hirano, Tetsushi ; Ikenaka, Yoshinori ; Hoshi, Nobuhiko
著者名
Nunobiki, Sarika
著者名
Yoshimoto, Ayano
著者名
Ito, Makiko
著者名
Yonoichi, Sakura
著者名
Hara, Yukako
著者名
Ishida, Yuya
著者名
Morishita, Rinako
著者ID
A1072
研究者ID
1000030724984
KUID
https://kuid-rm-web.ofc.kobe-u.ac.jp/search/detail.html?systemId=baf1f569c1518783520e17560c007669
著者名
Mantani, Youhei
万谷, 洋平
マンタニ, ヨウヘイ
所属機関名
農学研究科
著者ID
A0061
研究者ID
1000010380156
KUID
https://kuid-rm-web.ofc.kobe-u.ac.jp/search/detail.html?systemId=158c55140a1540e9520e17560c007669
著者名
Yokoyama, Toshifumi
横山, 俊史
ヨコヤマ, トシフミ
所属機関名
農学研究科
著者名
Hirano, Tetsushi
著者名
Ikenaka, Yoshinori
著者ID
A0039
研究者ID
1000010209223
著者名
Hoshi, Nobuhiko
星, 信彦
ホシ, ノブヒコ
所属機関名
農学研究科
言語
English (英語)
収録物名
Journal of Veterinary Medical Science
巻(号)
87(4)
ページ
411-418
出版者
Japanese Society of Veterinary Science
日本獣医学会
刊行日
2025-04
公開日
2025-05-09
抄録
Our previous reports showed that exposure to the neonicotinoid pesticide clothianidin (CLO) at a no-observed-adverse-effect-level (NOAEL) dose during fetal development and lactation in mice led to higher rates of maternal neglect and infanticide. Although the demonstrated association between decreased oxytocin secretion and decreased maternal parenting behavior implies a link to declining oxytocin levels, no evidence has yet emerged in CLO to clearly establish such an association. This study investigated the effects of CLO on maternal behavior and oxytocin in C57BL/6N mice exposed during pregnancy and lactation (F0 mothers) as well as in their adult female offspring (F1 mothers). The effects were assessed using nest building assays during pregnancy and pup retrieval assessment after delivery. The results showed a decrease in oxytocin secretion and a marked decrease in pup retrieval behavior among the F0 mothers in the CLO exposure group compared to those in the control group. Their offspring, the F1 mothers, showed significantly lower nest-building scores during pregnancy. In conclusion, this study is the first to examine the potential mechanisms by which CLO exposure in mothers at the NOAEL dose during pregnancy and lactation results in reduced plasma oxytocin levels, subsequently leading to a decline in maternal behaviors such as pup retrieval. Furthermore, these effects may impair maternal behaviors in the next generation, when the offspring mice become mothers.
キーワード
clothianidin
maternal behavior
nest building
oxytocin
pup retrieval
カテゴリ
農学研究科
学術雑誌論文
権利
© 2025 by the Japanese Society of Veterinary Science
CC license
This article is licensed under a Creative Commons [Attribution-NonCommercial-NoDerivatives 4.0 International] license.
関連情報
DOI
https://doi.org/10.1292/jvms.24-0372
PMID
39993733