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https://hdl.handle.net/20.500.14094/0100495929

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メタデータID
0100495929
アクセス権
open access
出版タイプ
Version of Record
タイトル
Midazolam with fentanyl for endobronchial ultrasound-guided transbronchial needle aspiration: a randomized, double-blind, phase III study
著者
Yamada, Jun ; Hazama, Daisuke ; Fukui, Takafumi ; Yatani, Atsuhiko ; Okamoto, Mariko ; Fujimoto, Shodai ; Yoshimura, Ryosuke ; Takayasu, Mizuki ; Takata, Naoya ; Sato, Hiroki ; Mimura, Chihiro ; Furukawa, Koichi ; Katsurada, Naoko ; Yamamoto, Masatsugu ; Tachihara, Motoko
著者名
Yamada, Jun
著者ID
A2841
研究者ID
1000030894604
KUID
https://kuid-rm-web.ofc.kobe-u.ac.jp/search/detail.html?systemId=35536a2922286287520e17560c007669
著者名
Hazama, Daisuke
羽間, 大祐
ハザマ, ダイスケ
所属機関名
医学研究科
著者名
Fukui, Takafumi
著者名
Yatani, Atsuhiko
著者名
Okamoto, Mariko
著者名
Fujimoto, Shodai
著者名
Yoshimura, Ryosuke
著者名
Takayasu, Mizuki
著者名
Takata, Naoya
著者名
Sato, Hiroki
著者名
Mimura, Chihiro
著者ID
A2762
研究者ID
1000030895131
著者名
Furukawa, Koichi
古川, 皓一
フルカワ, コウイチ
所属機関名
医学研究科
著者ID
A2117
研究者ID
1000030816195
KUID
https://kuid-rm-web.ofc.kobe-u.ac.jp/search/detail.html?systemId=6fa2a70acb2a0124520e17560c007669
著者名
Katsurada, Naoko
桂田, 直子
カツラダ, ナオコ
所属機関名
医学研究科
著者ID
A1538
研究者ID
1000040542139
KUID
https://kuid-rm-web.ofc.kobe-u.ac.jp/search/detail.html?systemId=183d9080319b2c1e520e17560c007669
著者名
Yamamoto, Masatsugu
山本, 正嗣
ヤマモト, マサツグ
所属機関名
医学部附属病院
著者ID
A1452
研究者ID
1000040448626
KUID
https://kuid-rm-web.ofc.kobe-u.ac.jp/search/detail.html?systemId=8a84f5066adebfb6520e17560c007669
著者名
Tachihara, Motoko
立原, 素子
タチハラ, モトコ
所属機関名
医学研究科
言語
English (英語)
収録物名
Lung Cancer
巻(号)
204
ページ
108556
出版者
Elsevier B.V.
刊行日
2025-06
公開日
2025-05-26
抄録
Background: Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) is a common technique for sampling mediastinal and hilar lymph nodes. However, the optimal sedation for EBUS-TBNA remains unclear. We aimed to evaluate the efficacy of adding fentanyl to midazolam. Materials and methods: We conducted a single-center, randomized, double-blind, phase III study. Patients who received midazolam with fentanyl (fentanyl group) were compared with those who received midazolam with placebo (placebo group) during EBUS-TBNA. The primary outcome was the proportion of patients meeting all three criteria: 1) adequate sedation (Modified Observer’s Assessment of Alertness and Sedation scale ≤4 or bispectral index values ≤80), 2) minimal additional sedation requirement (no more than two additional sedative administrations within the first 30 min), and 3) successful procedure completion (at least three EBUS-TBNA punctures). Results: A total of 84 patients (fentanyl group, 41; placebo group, 43) were enrolled. There were no significant differences in patient characteristics between the two groups. The primary outcome was significantly better in the fentanyl group than in the placebo group (46.3 % vs. 23.3 %, p = 0.038). A significantly lower rate of sedative-induced delirium, a lower number of additional sedative administrations, and a higher rate of ≥3 punctures were observed in the fentanyl group. There were no significant differences in complications. The operator visual analog scale questionnaire on cough, sputum, cooperation, and sedative effects was significantly better in the fentanyl group. Conclusion: Adding fentanyl to midazolam provided better sedation. Midazolam combined with fentanyl should be considered during EBUS-TBNA.
キーワード
EBUS-TBNA
Flexible bronchoscopy
Sedation
Midazolam with fentanyl
カテゴリ
医学研究科
医学部附属病院
学術雑誌論文
権利
© 2025 The Author(s). Published by Elsevier B.V.
CC license
This is an open access article under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International license
関連情報
DOI
https://doi.org/10.1016/j.lungcan.2025.108556
PMID
40345066