Phase II Protocol on the Safety and Nutritional Status of Postoperative Enteral Nutrition Using HINEX® E-gel LC in Patients with Esophageal Cancer Undergoing Minimally Invasive Esophagectomy

Kato, Takashi; Goto, Hironobu; Takahashi, Michiko; Koterazawa, Yasufumi; Sawada, Ryuichiro; Harada, Hitoshi; Urakawa, Naoki; Hasegawa, Hiroshi; Kanaji, Shingo; Yamashita, Kimihiro; Matsuda, Takeru; Oshikiri, Taro; Kakeji, Yoshihiro

doi:https://doi.org/10.24546/0100495984

https://doi.org/10.24546/0100495984

このアイテムのアクセス数:949件（2026-06-28 01:10 集計）

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メタデータID	0100495984
アクセス権	open access
出版タイプ	Version of Record
タイトル	Phase II Protocol on the Safety and Nutritional Status of Postoperative Enteral Nutrition Using HINEX® E-gel LC in Patients with Esophageal Cancer Undergoing Minimally Invasive Esophagectomy
著者	Kato, Takashi ; Goto, Hironobu ; Takahashi, Michiko ; Koterazawa, Yasufumi ; Sawada, Ryuichiro ; Harada, Hitoshi ; Urakawa, Naoki ; Hasegawa, Hiroshi ; Kanaji, Shingo ; Yamashita, Kimihiro ; Matsuda, Takeru ; Oshikiri, Taro ; Kakeji, Yoshihiro
著者名 Kato, Takashi
著者名 Goto, Hironobu
著者ID A1483 研究者ID 1000070570274 KUID https://kuid-rm-web.ofc.kobe-u.ac.jp/search/detail.html?systemId=2792ef5b57661b4c520e17560c007669 著者名 Takahashi, Michiko 高橋, 路子タカハシ, ミチコ所属機関名医学部附属病院
著者ID A3656 研究者ID 1000040824206 KUID https://kuid-rm-web.ofc.kobe-u.ac.jp/search/detail.html?systemId=c7cd02029eb37593520e17560c007669 著者名 Koterazawa, Yasufumi 小寺澤, 康文コテラザワ, ヤスフミ所属機関名医学部附属病院
著者名 Sawada, Ryuichiro
著者ID A3023 研究者ID 1000070771517 KUID https://kuid-rm-web.ofc.kobe-u.ac.jp/search/detail.html?systemId=6890d97a51055143520e17560c007669 著者名 Harada, Hitoshi 原田, 仁ハラダ, ヒトシ所属機関名医学部附属病院
著者ID A2526 研究者ID 1000020647763 KUID https://kuid-rm-web.ofc.kobe-u.ac.jp/search/detail.html?systemId=cee872a7fac91c14520e17560c007669 著者名 Urakawa, Naoki 裏川, 直樹ウラカワ, ナオキ所属機関名医学研究科
著者ID A1558 研究者ID 1000050529542 KUID https://kuid-rm-web.ofc.kobe-u.ac.jp/search/detail.html?systemId=70d816578161532d520e17560c007669 著者名 Hasegawa, Hiroshi 長谷川, 寛ハセガワ, ヒロシ所属機関名医学部附属病院
著者ID A1519 研究者ID 1000010637052 KUID https://kuid-rm-web.ofc.kobe-u.ac.jp/search/detail.html?systemId=508b6461f962866e520e17560c007669 著者名 Kanaji, Shingo 金治, 新悟カナジ, シンゴ所属機関名医学研究科
著者ID A1436 研究者ID 1000080535427 KUID https://kuid-rm-web.ofc.kobe-u.ac.jp/search/detail.html?systemId=a1b771806c49baeb520e17560c007669 著者名 Yamashita, Kimihiro 山下, 公大ヤマシタ, キミヒロ所属機関名医学部附属病院
著者ID A1537 研究者ID 1000030782734 KUID https://kuid-rm-web.ofc.kobe-u.ac.jp/search/detail.html?systemId=fcf7c52c66d495fa520e17560c007669 著者名 Matsuda, Takeru 松田, 武マツダ, タケル所属機関名医学研究科
著者ID A0849 研究者ID 1000030771498 著者名 Oshikiri, Taro 押切, 太郎オシキリ, タロウ所属機関名医学研究科
著者ID A1706 研究者ID 1000080284488 KUID https://kuid-rm-web.ofc.kobe-u.ac.jp/search/detail.html?systemId=2901d33e92e00ca4520e17560c007669 著者名 Kakeji, Yoshihiro 掛地, 吉弘カケジ, ヨシヒロ所属機関名医学研究科
言語	English (英語)
収録物名	The Kobe journal of the medical sciences
巻(号)	71(2)
ページ	50-55
出版者	Kobe Journal of Medical Sciences　刊行会
出版者	Kobe Journal of Medical Sciences
刊行日	2025
抄録	BACKGROUND: Enteral nutrition therapy in the early postperative period is essential for patients with esophageal cancer following esophagectomy. HINEX® E-gel LC is an Oligomeric formula with various nutrients, including dietary fiber pectin. It is expected to reduce symptoms, such as diarrhea, resulting in improved adherence and decreased rate of weight loss. However, no reports have examined the adherence to or efficacy of nutritional support therapy using HINEX® E-gel LC after esophagectomy. METHODS: This is a single-institution, single-arm phase Ⅱ trial. We plan to recruit 32 patients with esophageal cancer who have undergone minimally invasive esophagectomy (MIE) and place an enteral feeding tube. Enteral feeding is to be initiated on the second postoperative day, and the patients is to remain on enteral feeding at 300 kcal/day after discharge. The primary endpoints is adherence to enteral nutrition with HINEX® E-gel LC for up to 2 months postoperatively. The secondary endpoint is the association between the adherence to HINEX® E-gel LC and each nutritional parameter, such as hematological examination, body weight, and psoas muscle. DISCUSSION: Although enteral nutrition is usually initiated in the early postoperative period after esophagectomy, the use of fat-containing digestive agents in the early postoperative period is a novel approach. To the best of our knowledge, this study is the first to evaluate the safety and nutritional status of early postperative enteral nutrition using fat-containing digestive agents after MIE. Efficient nutritional support therapy using fat-containing digestive agents is expected to be especially useful after esophagectomy when oral intake is significantly decreased.
キーワード	Postoperative enteral nutrition
	Minimally invasive esophagectomy
	Oligomeric formula nutrient
カテゴリ	医学研究科
	医学部附属病院
	The Kobe journal of the medical sciences ＞ 71巻＞ 71巻2号（2025）
	紀要論文
権利	©2025 Kobe Journal of Medical Sciences Publisher.
権利	This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International License (CC-BY 4.0).

資源タイプ	departmental bulletin paper
ISSN	0023-2513　OPACで所蔵を検索　 CiNiiで学外所蔵を検索
NCID	AA00711740　OPACで所蔵を検索　 CiNiiで表示

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