神戸大学附属図書館デジタルアーカイブ
https://hdl.handle.net/20.500.14094/0100497283

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メタデータID
0100497283
アクセス権
open access
出版タイプ
Version of Record
タイトル
Association of metformin treatment with changes in metal dynamics in individuals with type 2 diabetes
著者
Otowa-Suematsu, Natsu ; Sakaguchi, Kazuhiko ; Yamada, Tomoko ; Nishisaka, Marika ; Morita, Yasuko ; Fukumitsu, Hayato ; Katsura, Yukari ; Okada, Yuko ; Hirota, Yushi ; Sugawara, Kenji ; Ogawa, Wataru
ORCID
0000-0003-4982-0336
著者名
Otowa-Suematsu, Natsu
著者ID
A1387
研究者ID
1000020444573
KUID
https://kuid-rm-web.ofc.kobe-u.ac.jp/search/detail.html?systemId=cc9462ee69a7a403520e17560c007669
著者名
Sakaguchi, Kazuhiko
坂口, 一彦
サカグチ, カズヒコ
所属機関名
医学研究科
著者ID
A3028
研究者ID
1000070925247
KUID
https://kuid-rm-web.ofc.kobe-u.ac.jp/search/detail.html?systemId=6ed10c22316db82f520e17560c007669
著者名
Yamada, Tomoko
山田, 倫子
ヤマダ, トモコ
所属機関名
医学部附属病院
著者名
Nishisaka, Marika
著者名
Morita, Yasuko
著者名
Fukumitsu, Hayato
著者名
Katsura, Yukari
著者名
Okada, Yuko
著者ID
A1420
研究者ID
1000080566018
KUID
https://kuid-rm-web.ofc.kobe-u.ac.jp/search/detail.html?systemId=8d8b694f29475700520e17560c007669
著者名
Hirota, Yushi
廣田, 勇士
ヒロタ, ユウシ
所属機関名
医学研究科
著者ID
A2560
研究者ID
1000070645217
KUID
https://kuid-rm-web.ofc.kobe-u.ac.jp/search/detail.html?systemId=c2bace40c3a023c1520e17560c007669
著者名
Sugawara, Kenji
菅原, 健二
スガワラ, ケンジ
所属機関名
医学部附属病院
著者ID
A1358
研究者ID
1000040294219
KUID
https://kuid-rm-web.ofc.kobe-u.ac.jp/search/detail.html?systemId=38228987a3a438c8520e17560c007669
著者名
Ogawa, Wataru
小川, 渉
オガワ, ワタル
所属機関名
医学研究科
言語
English (英語)
収録物名
BMJ Open Diabetes Research & Care
巻(号)
13(5)
ページ
e005255
出版者
BMJ
刊行日
2025-08-31
公開日
2025-09-03
抄録
【Introduction】 The metal-chelating activity of metformin, which has long been known but of unclear clinical relevance, has recently been implicated in the pleiotropic effects, including antitumorigenic and anti-inflammatory actions, of the drug. However, whether metformin actually influences metal dynamics in humans has remained unknown. We here investigate whether metformin influences serum metal levels in individuals with type 2 diabetes. 【Research design and methods】 In this cross-sectional study, individuals with type 2 diabetes treated or not treated with metformin for at least 6 months were recruited. The primary outcome was the difference in serum copper concentration between metformin users and non-users. Secondary outcomes included differences in serum levels of iron, zinc, and vitamin B12 as well as in copper-related and iron-related parameters between the two groups. 【Results】 A total of 189 individuals (93 metformin users and 96 non-users) were analyzed. Metformin users showed significantly lower serum copper (16.0 vs 17.8 µmol/L, p<0.001) and iron levels (16.3 vs 17.3 µmol/L, p=0.02) and higher zinc levels (13.3 vs 12.5 µmol/L, p=0.01) compared with non-users. Copper-related and iron-related parameters for metformin users were consistent with latent deficiencies of these metals. Serum homocysteine levels (12.2 vs 11.2 µmol/L, p=0.03) were significantly higher, whereas vitamin B12 levels (338.7 vs 412.8 pmol/L, p<0.001) were significantly lower, in metformin users. Multiple regression analysis including variables that potentially influence metal dynamics identified metformin use as an independent predictor of serum copper (B = –1.54 µmol/L, p<0.001) and iron levels (B = –2.49 µmol/L, p=0.004). 【Conclusions】 Metformin use was associated with reduced serum levels of copper and iron, as well as with increased serum zinc levels. These changes in metal dynamics may be related to the pharmacological effects of this widely administered drug.
カテゴリ
医学研究科
医学部附属病院
学術雑誌論文
権利
© Author(s) (or their employer(s)) 2025.
CC license
Creative Commons Attribution-NonCommercial 4.0 Internatinal License
関連情報
DOI
https://doi.org/10.1136/bmjdrc-2025-005255