神戸大学附属図書館デジタルアーカイブ
https://hdl.handle.net/20.500.14094/0100498998

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ファイル出力

メタデータID
0100498998
アクセス権
open access
出版タイプ
Version of Record
タイトル
Unraveling the Cardiorenal Nexus　― Emerging Frameworks and the Role of Exercise Therapy ―
著者
著者ID
A1350
研究者ID
1000010736185
KUID
https://kuid-rm-web.ofc.kobe-u.ac.jp/search/detail.html?systemId=3330637c7f4d6307520e17560c007669
著者名
Izawa, P. Kazuhiro
井澤, 和大
イザワ, カズヒロ
所属機関名
保健学研究科
著者名
Ogura, Asami
言語
English (英語)
収録物名
Circulation Reports
巻(号)
8(3)
ページ
381-390
出版者
The Japanese Circulation Society
一般社団法人 日本循環器学会
刊行日
2026-03-10
公開日
2025-12-26
注記
Advance online publication: 2025-12-26. Advance online publication で公開していましたが、刊行後のファイルに差し替えました。(2026-03-10)
抄録
Background: Chronic kidney disease and cardiovascular disease (CKD-CVD) frequently coexist, creating challenges to prognosis, exercise capacity, and quality of life (QOL). CKD is common across cardiovascular conditions, underscoring the need for comprehensive management. Newer concepts of cardiovascular-kidney-metabolic syndrome (CKM) and chronic cardiovascular-kidney disorder (CCKD) emphasize shared risk factors and interconnected pathophysiological mechanisms. Within this paradigm, exercise therapy has emerged as a promising intervention to improve exercise capacity. Methods and Results: This narrative review synthesizes conceptual advancements in the CKM-CCKD frameworks and summarizes recent literature on exercise therapy within these frameworks. The CKM-CCKD frameworks highlight the importance of addressing common risk factors and mechanisms underlying CKD-CVD. Exercise therapy comprising individualized aerobic programs is being increasingly recognized for its potential. However, its effectiveness can be limited by factors such as anemia, which correlates with impaired peak oxygen uptake and anaerobic thresholds in patients with renal dysfunction. Tailored regimens addressing reduced capacity, multimorbidity, and psychosocial factors, including patient-reported outcomes, further support inclusivity and effectiveness in clinical practice. Conclusions: Within the CKM-CCKD frameworks, exercise therapy represents an important strategy to target shared risk factors and mechanisms in CKD-CVD. Future work should emphasize evidence-based interventions, early implementation, and individualized approaches to strengthen the translational value of these frameworks and improve QOL in this high-risk population.
キーワード
Anemia management
Cardiorenal syndrome
Cardiovascular disease
Cardiovascular-kidney-metabolic syndrome
Chronic cardiovascular-kidney disorder
Chronic kidney disease
Exercise capacity
Quality of life
カテゴリ
保健学研究科
学術雑誌論文
権利
© 2025, THE JAPANESE CIRCULATION SOCIETY
CC license
This article is licensed under a Creative Commons [Attribution-NonCommercial-NoDerivatives 4.0 International] license
関連情報
DOI
https://doi.org/10.1253/circrep.cr-25-0198