81000115

open access

Version of Record

Studies on Fungal Pumilio Gene Family through Mining Multiple Genome-Scale Data Sets

English (英語)

The Kobe journal of the medical sciences

53(4)

163-169

Kobe University School of Medicine

2007-08

2008-02-20

The genes belonging to Pumilio gene family of the fission yeast Schizosaccharomycespombe (S. pombe) were compared with genome information of the several fungi andtheir functions have been inferred using public-access databases disclosed on theinternet websites.The Pumilio-family genes are conserved from yeast to man and have beenconsidered to suppress the expression of other genes by binding their specific targetmessenger RNAs. In S. pombe genome, nine genes belonging to Pumilio gene familywere found and were clustered into four groups by homology of their amino acidsequences. Each gene has been analyzed to search `close orthologue' in the genomesof Saccharomyces cerevisiae, Candida parapsilosis, Aspergillus fumigatus, Phytophthorainfestans, Pneumocystis carinii and Neurospora crassa, using protein-protein blast Psearch.Consequently, we found several genes belonging to Pumilio gene family in thegenomes of Saccharomyces cerevisiae, Candida parapsilosis, and Neurospora crassa.Evolution and function of these genes can be expected from the analysis based on themolecular phylogenies.

bioinformatics

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