神戸大学附属図書館デジタルアーカイブ
https://doi.org/10.24546/81000117

このアイテムのアクセス数:70件（2026-08-11 08:37 集計）

閲覧可能ファイル 

ファイル フォーマット サイズ 閲覧回数 説明
81000117 (fulltext) pdf 244 KB 31

メタデータ

ファイル出力

メタデータID
81000117
アクセス権
open access
出版タイプ
Version of Record
タイトル
Correlative Expression of Cyclooxygenase-1 (Cox-1) and Human Epidermal Growth Factor Receptor Type-2 (Her-2) in Endometrial Cancer
著者
Sugimoto, Takeshi ; Koizumi, Tamio ; Sudo, Tamotsu ; Yamaguchi, Satoshi ; Kojima, Atsumi ; Kumagai, Shunichi ; Nishimura, Ryuichirou
著者名
Sugimoto, Takeshi
著者名
Koizumi, Tamio
著者名
Sudo, Tamotsu
著者名
Yamaguchi, Satoshi
著者名
Kojima, Atsumi
著者名
Kumagai, Shunichi
著者名
Nishimura, Ryuichirou
言語
English (英語)
収録物名
The Kobe journal of the medical sciences
巻(号)
53(5)
ページ
177-187
出版者
神戸大学医学部
Kobe University School of Medicine
刊行日
2007-01
公開日
2008-02-20
抄録
Objectives: Cyclooxygenase-2 (Cox-2) is known to be associated with tumorigenesisin many cancers including endometrial cancer, while there is substantial evidence forthe tumorigenicity of cyclooxygenase-1 (Cox-1). However, little is known about theinvolvement of Cox-1 in the development of endometrial cancer. The aim of this studywas to determine whether cyclooxygenase-1 or -2 (Cox-1, Cox-2) is tumorigenetic, aswell as whether these two cyclooxygenase isoforms correlate with theclinicopathological characteristics or with another two biomarkers, human epidermalgrowth factor receptor type-2 (Her-2) and vascular endothelial growth factor (VEGF),of endometrial cancer.Methods: At first, Cox-1 and Cox-2 levels in eight endometrial cancer cell lines weredetermined by means of real-time PCR. At second, the levels of four biomarkers (Cox-1,Cox-2, Her-2, and VEGF) in 70 endometrial cancer samples were determined by meansof real-time PCR. Pairs of these biomarkers were subjected to correlation as eachbiomarker and clinical status or survival.Results: In the eight cell lines, the expression of Cox-1 and Cox-2 showed majorvariations in their mRNA levels. Analysis of the patient samples showed that the mRNAexpression of Cox-1 was elevated significantly in the G1 (P=0.021) and G2 (P=0.036)groups, as was the mRNA expression of Her-2 in the two groups (P=0.036 and P=0.0029,respectively). The mRNA expression of Cox-1 and Her-2 were correlated (CI=0.671).None of the three biomarkers, Cox-1, Cox-2, and Her-2, was correlated with clinicalstatus such as FIGO classification, myometrial invasion, or clinical outcome.Conclusion: Cox-1, together with Her-2, may be involved in the early stage ofendometrial cancer development.
キーワード
Cyclooxygenase-1 (Cox-1)
Human epidermal growth factor receptor type-2 (Her-2)
Cyclooxygenase-2 (Cox-2)
Vascular endothelial growth factor (VEGF)
Endometrial cancer
カテゴリ
The Kobe journal of the medical sciences ＞ 53巻 ＞ 53巻5号（2007-01）
紀要論文
関連情報
NAID
110006646788　CiNiiで表示
URI
http://www.med.kobe-u.ac.jp/journal/contents.html