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https://doi.org/10.24546/81000134

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メタデータID
81000134
アクセス権
open access
出版タイプ
Version of Record
タイトル
Association of Serum MCP-1 Concentration and MCP-1 Polymorphism with Insulin Resistance in Japanese Individuals with Obese type 2 Diabetes
著者
Kouyama, Kunichi ; Miyake, Kazuaki ; Zenibayashi, Masako ; Hirota, Yushi ; Teranishi, Tetsuya ; Tamori, Yoshikazu ; Kanda, Hajime ; Sakaguchi, Kazuhiko ; Ohara, Takeshi ; Kasuga, Masato
著者名
Kouyama, Kunichi
著者名
Miyake, Kazuaki
著者名
Zenibayashi, Masako
著者名
Hirota, Yushi
著者名
Teranishi, Tetsuya
著者ID
A1938
研究者ID
1000090379397
KUID
https://kuid-rm-web.ofc.kobe-u.ac.jp/search/detail?systemId=fc3ce686271f4d14520e17560c007669
著者名
Tamori, Yoshikazu
田守, 義和
タモリ, ヨシカズ
所属機関名
医学研究科
著者名
Kanda, Hajime
著者名
Sakaguchi, Kazuhiko
著者名
Ohara, Takeshi
著者名
Kasuga, Masato
言語
English (英語)
収録物名
The Kobe journal of the medical sciences
巻(号)
53(6)
ページ
345-354
出版者
神戸大学医学部
Kobe University School of Medicine
刊行日
2007-12
公開日
2008-02-20
抄録
Monocyte chemoattractant protein-1 (MCP-1, also known as CCL2) secreted byadipocytes is a member of the CC chemokine family and plays a pivotal role in theinflammatory process. A polymorphism, the -2518 A/G of MCP-1 gene, has beenassociated with type 2 diabetes, type 1 diabetes, parameters of insulin resistance andobesity. Therefore, we investigated the effects of MCP-1 single nucleotidepolymorphisms (SNPs) on the susceptibility to type 2 diabetes or insulin resistance inthe Japanese population. We also assessed the correlation between serum MCP-1concentration and other clinical characteristics in Japanese type 2 diabetic subjects.The serum MCP-1 concentration was significantly correlated with HOMA-IR and thevisceral fat area, but not with BMI. Although there was no association between thisSNP and type 2 diabetes, the -2518A/G polymorphism was associated with the serumMCP-1 concentration. In subgroup analysis, Japanese obese diabetic -2518AA carriershad a higher MCP-1 concentration and increased insulin resistance than obese diabetic-2518G carriers. These data indicated that the MCP-1 polymorphism was associatedwith insulin resistance in Japanese obese diabetic subjects and that MCP-1 wasimplicated in the pathogenesis of insulin resistance, especially associated with obesity,in humans.
キーワード
MCP-1
polymorphism
insulin resistance
diabetes
カテゴリ
医学研究科
The Kobe journal of the medical sciences ＞ 53巻 ＞ 53巻6号（2007-12）
紀要論文
関連情報
NAID
110006648080　CiNiiで表示
URI
http://www.med.kobe-u.ac.jp/journal/contents.html