神戸大学附属図書館デジタルアーカイブ
https://doi.org/10.24546/81000135

このアイテムのアクセス数:53件（2026-08-11 08:32 集計）

閲覧可能ファイル 

ファイル フォーマット サイズ 閲覧回数 説明
81000135 (fulltext) pdf 155 KB 27

メタデータ

ファイル出力

メタデータID
81000135
アクセス権
open access
出版タイプ
Version of Record
タイトル
Reversal Effects of Ca2+ Antagonists on Multidrug Resistance via Down-regulation of MDR1 mRNA
著者
Komoto, Chiho ; Nakamura, Tsutomu ; Yamamori, Motohiro ; Ohmoto, Nobuko ; Kobayashi, Hironao ; Kuwahara, Akiko ; Nishiguchi, Kohshi ; Takara, Kohji ; Tanigawara, Yusuke ; Okamura, Noboru ; Okumura, Katsuhiko ; Sakaeda, Toshiyuki
著者名
Komoto, Chiho
著者名
Nakamura, Tsutomu
著者名
Yamamori, Motohiro
著者名
Ohmoto, Nobuko
著者名
Kobayashi, Hironao
著者名
Kuwahara, Akiko
著者名
Nishiguchi, Kohshi
著者名
Takara, Kohji
著者名
Tanigawara, Yusuke
著者名
Okamura, Noboru
著者名
Okumura, Katsuhiko
著者名
Sakaeda, Toshiyuki
言語
English (英語)
収録物名
The Kobe journal of the medical sciences
巻(号)
53(6)
ページ
355-363
出版者
神戸大学医学部
Kobe University School of Medicine
刊行日
2007-12
公開日
2008-02-20
抄録
In previous reports, the effects of 12 Ca2+ antagonists on a multidrug resistanttransporter, P-glycoprotein/MDR1, were evaluated in terms of those onMDR1-mediated transport of [3H]digoxin and the sensitivity of vinblastine sulfate orpaclitaxel, and they were able to be classified into 4 subgroups based on their actions,as those with transport inhibition and sensitivity recovery, those with or withouttransport inhibition but marginal sensitivity recovery, and those without both. Inthis study, our previous findings were confirmed by the resistance against doxorubicinhydrochloride and daunorubicin hydrochloride, and by the recovery of [3H] vinblastinesulfate accumulation. Furthermore, it was found that the effects of 12 Ca2+antagonists on the sensitivity recovery were also explained by the down-regulation ofMDR1 mRNA, suggesting a novel mechanism to reverse the MDR1-mediatedmultidrug resistance.
キーワード
MDR1/P-glycoprotein
Ca2+ antagonist
multidrug resistance
down-regulation
mRNA expression
カテゴリ
The Kobe journal of the medical sciences ＞ 53巻 ＞ 53巻6号（2007-12）
紀要論文
関連情報
NAID
110006648092　CiNiiで表示
URI
http://www.med.kobe-u.ac.jp/journal/contents.html