An Open-Label, Multi-Institutional, Randomized Study to Evaluate the Additive Effect of a Leukotriene Receptor Antagonist on Cough Score in Patients with Cough-Variant Asthma Being Treated with Inhaled Corticosteroids

Miwa, Nanako; Nagano, Tatsuya; Ohnishi, Hisashi; Nishiuma, Teruaki; Takenaka, Kazuhiro; Shirotani, Tomohiko; Nakajima, Takeo; Dokuni, Ryota; Kawa, Yoshitaka; Kobayashi, Kazuyuki; Funada, Yasuhiro; Kotani, Yoshikazu; Nishimura, Yoshihiro

doi:https://doi.org/10.24546/81010590

https://doi.org/10.24546/81010590

このアイテムのアクセス数:473件（2026-08-11 08:38 集計）

閲覧可能ファイル

ファイル	フォーマット	サイズ	閲覧回数	説明
81010590 (fulltext)	pdf	322 KB	106

メタデータ

ファイル出力

メタデータID	81010590
アクセス権	open access
出版タイプ	Version of Record
タイトル	An Open-Label, Multi-Institutional, Randomized Study to Evaluate the Additive Effect of a Leukotriene Receptor Antagonist on Cough Score in Patients with Cough-Variant Asthma Being Treated with Inhaled Corticosteroids
著者	Miwa, Nanako ; Nagano, Tatsuya ; Ohnishi, Hisashi ; Nishiuma, Teruaki ; Takenaka, Kazuhiro ; Shirotani, Tomohiko ; Nakajima, Takeo ; Dokuni, Ryota ; Kawa, Yoshitaka ; Kobayashi, Kazuyuki ; Funada, Yasuhiro ; Kotani, Yoshikazu ; Nishimura, Yoshihiro
著者名 Miwa, Nanako
著者ID A0860 研究者ID 1000080624684 KUID https://kuid-rm-web.ofc.kobe-u.ac.jp/search/detail?systemId=a3a21385ba2a8535520e17560c007669 著者名 Nagano, Tatsuya 永野, 達也ナガノ, タツヤ所属機関名医学研究科
著者名 Ohnishi, Hisashi
著者名 Nishiuma, Teruaki
著者名 Takenaka, Kazuhiro
著者名 Shirotani, Tomohiko
著者名 Nakajima, Takeo
著者名 Dokuni, Ryota
著者名 Kawa, Yoshitaka
著者ID A1406 研究者ID 1000050403275 KUID https://kuid-rm-web.ofc.kobe-u.ac.jp/search/detail?systemId=de40a5d6e8d38137520e17560c007669 著者名 Kobayashi, Kazuyuki 小林, 和幸コバヤシ, カズユキ所属機関名医学部附属病院
著者名 Funada, Yasuhiro
著者名 Kotani, Yoshikazu
著者ID A0759 研究者ID 1000020291453 KUID https://kuid-rm-web.ofc.kobe-u.ac.jp/search/detail?systemId=cadf586815c97cd6520e17560c007669 著者名 Nishimura, Yoshihiro 西村, 善博ニシムラ, ヨシヒロ所属機関名医学部附属病院
言語	English (英語)
収録物名	The Kobe journal of the medical sciences
巻(号)	64(4)
ページ	134-139
出版者	神戸大学医学部
出版者	Kobe University School of Medicine
刊行日	2018
公開日	2018-12-14
抄録	Cough-variant asthma is one of the most common reasons for chronic cough. It is important to treat appropriately cough-variant asthma because 30% to 40% of cough-variant asthma becomes a typical asthma. However, little is known about the treatment of cough-variant asthma except for inhaled corticosteroid (ICS). The aim of this study was to validate the additive efficacy of a leukotriene receptor antagonist (LTRA) on cough score and respiratory function in patients with cough-variant asthma being treated with ICS. A total 28 patients were randomly assigned to either an ICS + LTRA group or an ICS group. There were statistically significant improvements in cough scores in the ICS + LTRA group from 0 weeks (6.7 ± 4.4) to 2 weeks (2.9 ± 3.2) (P < 0.05), 4 weeks (0.7 ± 1.1) (P < 0.001), and 8 weeks (0.8 ± 1.2) (P < 0.001). However similar improvements were not evident in the ICS group from 0 weeks (6.7 ± 4.4) to 2 weeks (5.6 ± 10.0) (P = 0.59), 4 weeks (4.6 ± 7.6) (P = 0.32), and 8 weeks (2.9 ± 5.2) (P = 0.08). On the other hand, no significant changes were evident in the forced expiratory volume in 1 s (FEV1) and FEV1/forced vital capacity (FVC). In conclusion, the LTRA was useful in improving cough in patients with cough-variant asthma, even though it appeared to be ineffective in improving respiratory function.
カテゴリ	医学研究科
	医学部附属病院
	The Kobe journal of the medical sciences ＞ 64巻＞ 64巻4号（2018）
	紀要論文
関連情報	URI http://www.med.kobe-u.ac.jp/journal/contents.html

資源タイプ	departmental bulletin paper
ISSN	0023-2513　OPACで所蔵を検索　 CiNiiで学外所蔵を検索
NCID	AA00711740　OPACで所蔵を検索　 CiNiiで表示

閲覧可能ファイル

メタデータ

詳細を表示