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https://hdl.handle.net/20.500.14094/90006004
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2024-09-01
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90006004 (fulltext)
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メタデータID
90006004
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open access
出版タイプ
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タイトル
Mitochondrial DNA Copy Number Raises the Potential of Left Frontopolar Hemodynamic Response as a Diagnostic Marker for Distinguishing Bipolar Disorder From Major Depressive Disorder
著者
Tsujii, Noa ; Otsuka, Ikuo ; Okazaki, Satoshi ; Yanagi, Masaya ; Numata, Shusuke ; Yamaki, Naruhisa ; Kawakubo, Yoshihiro ; Shirakawa, Osamu ; Hishimoto, Akitoyo
著者名
Tsujii, Noa
著者ID
A1560
研究者ID
1000040722880
著者名
Otsuka, Ikuo
大塚, 郁夫
オオツカ, イクオ
所属機関名
医学部附属病院
著者名
Okazaki, Satoshi
著者名
Yanagi, Masaya
著者名
Numata, Shusuke
著者名
Yamaki, Naruhisa
著者名
Kawakubo, Yoshihiro
著者名
Shirakawa, Osamu
著者ID
A1307
研究者ID
1000050529526
KUID
https://kuid-rm-web.ofc.kobe-u.ac.jp/search/detail?systemId=0db51c6a70a77f9c520e17560c007669
著者名
Hishimoto, Akitoyo
菱本, 明豊
ヒシモト, アキトヨ
所属機関名
医学研究科
言語
English (英語)
収録物名
Frontiers in Psychiatry
巻(号)
10
ページ
312-312
出版者
Frontiers Media
刊行日
2019-05-08
公開日
2019-05-22
抄録
Background: Given a lack of markers, diagnoses of bipolar disorder (BD) and major depressive disorder (MDD) rely on clinical assessment of symptoms. However, the depressive mood states of BD and depressive symptoms of MDD are often difficult to distinguish, which leads to misdiagnoses, which in turn leads to inadequate treatment. Previous studies have shown that the hemodynamic responses of the left frontopolar cortex measured by near-infrared spectroscopy (NIRS) differ between BD and MDD; these hemodynamic responses are associated with altered mitochondrial metabolism; and mitochondrial DNA copy number (mtDNAcn), an index of mitochondrial dysfunction, tends to decrease in BD and increase in MDD patients. In this study, we confirmed that mtDNAcn trends in opposite directions in BD and MDD. We then determined whether mtDNAcn could enhance the utility of NIRS as a diagnostic marker to distinguish between BD and MDD. Methods: We determined mtDNAcn in peripheral blood samples from 58 healthy controls, 79 patients with BD, and 44 patients with MDD. Regional hemodynamic responses during a verbal fluency task (VFT) in 24 BD patients and 44 MDD patients, matched by age and depression severity, were monitored using NIRS. Results: Measurements of mtDNAcn were lower in BD patients and higher in MDD patients than in controls. The left frontopolar region exhibited the most significant differences in mean VFT-related oxy-Hb changes between the BD and MDD groups. Multivariate logistic regression analysis with variables including age, sex, hemodynamic response of the left frontopolar region, and mtDNAcn showed high accuracy for distinguishing BD from MDD (area under the curve = 0.917; 95% confidence interval = 0.849-0.985). For the BD group, we observed a positive correlation between hemodynamic responses in the left frontopolar region and mtDNAcn, while for the MDD group, we observed a negative correlation. Conclusions: Our findings suggest that the association between hemodynamic response and mitochondrial dysfunction in BD or MDD plays an important role in differentiating the pathophysiological mechanisms of BD from those of MDD.
キーワード
bipolar disorder
major depressive disorder
hemodynamics
mitochondria
near-infrared spectroscopy
カテゴリ
医学研究科
医学部附属病院
学術雑誌論文
権利
© 2019 Tsujii, Otsuka, Okazaki, Yanagi, Numata, Yamaki, Kawakubo, Shirakawa and Hishimoto.
This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
関連情報
DOI
https://doi.org/10.3389/fpsyt.2019.00312
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資源タイプ
journal article
eISSN
1664-0640
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