Overexpression of CD 133 and BCL-2 in non-small cell lung cancer with neuroendocrine differentiation after transformation in ALK rearrangement-positive adenocarcinoma

Koyama, Kiyoko; Katsurada, Naoko; Jimbo, Naoe; Tachihara, Motoko; Tamura, Daisuke; Nakata, Kyosuke; Nagano, Tatsuya; Yamamoto, Masatsugu; Kamiryo, Hiroshi; Kobayashi, Kazuyuki; Itoh, Tomoo; Nishimura, Yoshihiro

https://hdl.handle.net/20.500.14094/90006230

このアイテムのアクセス数:312件（2026-08-11 16:11 集計）

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メタデータID	90006230
アクセス権	open access
出版タイプ	Accepted Manuscript
タイトル	Overexpression of CD 133 and BCL-2 in non-small cell lung cancer with neuroendocrine differentiation after transformation in ALK rearrangement-positive adenocarcinoma
著者	Koyama, Kiyoko ; Katsurada, Naoko ; Jimbo, Naoe ; Tachihara, Motoko ; Tamura, Daisuke ; Nakata, Kyosuke ; Nagano, Tatsuya ; Yamamoto, Masatsugu ; Kamiryo, Hiroshi ; Kobayashi, Kazuyuki ; Itoh, Tomoo ; Nishimura, Yoshihiro
著者名 Koyama, Kiyoko
著者ID A2117 研究者ID 1000030816195 KUID https://kuid-rm-web.ofc.kobe-u.ac.jp/search/detail?systemId=6fa2a70acb2a0124520e17560c007669 著者名 Katsurada, Naoko 桂田, 直子カツラダ, ナオコ所属機関名医学部附属病院
著者名 Jimbo, Naoe
著者ID A1452 研究者ID 1000040448626 KUID https://kuid-rm-web.ofc.kobe-u.ac.jp/search/detail?systemId=8a84f5066adebfb6520e17560c007669 著者名 Tachihara, Motoko 立原, 素子タチハラ, モトコ所属機関名医学研究科
著者名 Tamura, Daisuke
著者ID A0848 研究者ID 1000090566168 著者名 Nakata, Kyosuke 中田, 恭介ナカタ, キョウスケ所属機関名医学部附属病院呼吸器内科
著者ID A0860 研究者ID 1000080624684 KUID https://kuid-rm-web.ofc.kobe-u.ac.jp/search/detail?systemId=a3a21385ba2a8535520e17560c007669 著者名 Nagano, Tatsuya 永野, 達也ナガノ, タツヤ所属機関名医学研究科
著者ID A1538 研究者ID 1000040542139 KUID https://kuid-rm-web.ofc.kobe-u.ac.jp/search/detail?systemId=183d9080319b2c1e520e17560c007669 著者名 Yamamoto, Masatsugu 山本, 正嗣ヤマモト, マサツグ所属機関名医学部附属病院
著者ID A0838 研究者ID 1000050718351 著者名 Kamiryo, Hiroshi 上領, 博カミリョウ, ヒロシ所属機関名大学院医学研究科医科学専攻
著者ID A1406 研究者ID 1000050403275 KUID https://kuid-rm-web.ofc.kobe-u.ac.jp/search/detail?systemId=de40a5d6e8d38137520e17560c007669 著者名 Kobayashi, Kazuyuki 小林, 和幸コバヤシ, カズユキ所属機関名医学部附属病院
著者ID A0047 研究者ID 1000020301880 KUID https://kuid-rm-web.ofc.kobe-u.ac.jp/search/detail?systemId=f4a9ec44690e3908520e17560c007669 著者名 Itoh, Tomoo 伊藤, 智雄イトウ, トモオ所属機関名医学部附属病院
著者ID A0759 研究者ID 1000020291453 KUID https://kuid-rm-web.ofc.kobe-u.ac.jp/search/detail?systemId=cadf586815c97cd6520e17560c007669 著者名 Nishimura, Yoshihiro 西村, 善博ニシムラ, ヨシヒロ所属機関名医学部附属病院
言語	English (英語)
収録物名	Pathology International
巻(号)	69(5)
ページ	294-299
出版者	Wiley
刊行日	2019-05
公開日	2020-06-01
抄録	Transformation to small cell lung cancer is one phenomenon of acquired resistance to anaplastic lymphoma kinase (ALK) tyrosine kinase inhibitors in ALK rearrangement-positive non-small cell lung cancer (NSCLC). Few case reports have focused on other types of histological transformation. We report a case of transformation of ALK rearrangement-positive adenocarcinoma to NSCLC with neuroendocrine differentiation during alectinib therapy. A 36-year-old woman presented with a tumor in the left lower lobe and bone metastases. She was diagnosed with ALK rearrangement-positive adenocarcinoma by histopathology of the primary tumor. Alectinib had been effective for 8 months before new lesions appeared. Histopathological re-examination of a recurrent tumor revealed poorly differentiated carcinoma with insulinoma-associated protein 1 (INSM1) expression, which remained ALK-positive. Expression of CD133, BCL-2, and SOX2 was positive in comparison to the initial tumor. Expression of SOX2 became more strongly positive than it was before treatment. The immunohistochemical findings of these markers associated with cancer stem-like cells and/or neuroendocrine differentiation suggest that cancer stem cells play a role in the mechanisms of histological transformation and acquired resistance of ALK rearrangement-positive cancer. To our knowledge, this is the first report to suggest an association between cancer stem-like cells and histological transformation in ALK rearrangement-positive lung cancer.
キーワード	adenocarcinoma
	ALK rearrangement-positive lung cancer
	cancer stem cell
	neuroendocrine carcinoma
	small cell lung cancer
	transformation
カテゴリ	医学研究科
	医学部附属病院
	学術雑誌論文
権利	© 2019 Japanese Society of Pathology and John Wiley & Sons Australia, Ltd. This is the peer reviewed version of the following article: [Pathology International, 69(5):294-299, 2019], which has been published in final form at https://doi.org/10.1111/pin.12782. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.
関連情報	DOI https://doi.org/10.1111/pin.12782

資源タイプ	journal article
ISSN	1320-5463　OPACで所蔵を検索　 CiNiiで学外所蔵を検索
eISSN	1440-1827　OPACで所蔵を検索　 CiNiiで学外所蔵を検索
NCID	AA10984364　OPACで所蔵を検索　 CiNiiで表示

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