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https://hdl.handle.net/20.500.14094/90006922

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メタデータID
90006922
アクセス権
open access
出版タイプ
Version of Record
タイトル
Dynamic Contrast-enhanced Area-detector CT vs Dynamic Contrast-enhanced Perfusion MRI vs FDG-PET/CT: Comparison of Utility for Quantitative Therapeutic Outcome Prediction for NSCLC Patients Undergoing Chemoradiotherapy
著者
Seki, Shinichiro ; Fujisawa, Yasuko ; Yui, Masao ; Kishida, Yuji ; Koyama, Hisanobu ; Ohyu, Shigeharu ; Sugihara, Naoki ; Yoshikawa, Takeshi ; Ohno, Yoshiharu
著者ID
A1521
研究者ID
1000030773519
著者名
Seki, Shinichiro
関, 紳一郎
セキ, シンイチロウ
所属機関名
医学研究科
著者名
Fujisawa, Yasuko
著者名
Yui, Masao
著者名
Kishida, Yuji
著者名
Koyama, Hisanobu
著者名
Ohyu, Shigeharu
著者名
Sugihara, Naoki
著者ID
A1739
研究者ID
1000040332788
KUID
https://kuid-rm-web.ofc.kobe-u.ac.jp/search/detail?systemId=b4c84d4c6cab31fc520e17560c007669
著者名
Yoshikawa, Takeshi
吉川, 武
ヨシカワ, タケシ
所属機関名
医学研究科
著者ID
A0772
研究者ID
1000030324924
著者名
Ohno, Yoshiharu
大野, 良治
オオノ, ヨシハル
所属機関名
医学研究科
言語
English (英語)
収録物名
Magnetic Resonance in Medical Sciences
巻(号)
19(1)
ページ
29-39
出版者
Japanese Society for Magnetic Resonance in Medicine
刊行日
2020
公開日
2020-03-17
抄録
Purpose: To directly compare the utility for therapeutic outcome prediction of dynamic first-pass contrast-enhanced (CE)-perfusion area-detector computed tomography (ADCT), MR imaging assessed with the same mathematical method and 2-[fluorine-18]-fluoro-2-deoxy-d-glucose–positron emission tomography combined with CT (PET/CT) for non-small cell lung cancer (NSCLC) patients treated with chemoradiotherapy. Materials and Methods: Forty-three consecutive stage IIIB NSCLC patients, consisting of 25 males (mean age ± standard deviation: 66.6 ± 8.7 years) and 18 females (66.4 ± 8.2 years) underwent PET/CT, dynamic CE-perfusion ADCT and MR imaging, chemoradiotherapy, and follow-up examination. In each patient, total, pulmonary arterial, and systemic arterial perfusions were calculated from both perfusion data and SUVmax on PET/CT, assessed for each targeted lesion, and averaged to determine final values. Receiver operating characteristics analyses were performed to compare the utility for distinguishing responders from non-responders using Response Evaluation Criteria in Solid Tumor (RECIST) 1.1 criteria. Overall survival (OS) assessed with each index were compared between two groups by means of the Kaplan–Meier method followed by the log-rank test. Results: Area under the curve (Az) for total perfusion on ADCT was significantly larger than that of pulmonary arterial perfusion (P < 0.05). Az of total perfusion on MR imaging was significantly larger than that of pulmonary arterial perfusion (P < 0.05). Mean OS of responder and non-responder groups were significantly different for total and systemic arterial (P < 0.05) perfusion. Conclusion: Dynamic first-pass CE-perfusion ADCT and MR imaging as well as PET/CT are useful for early prediction of treatment response by NSCLC patients treated with chemoradiotherapy.
キーワード
computed tomography
magnetic resonance imaging
non-small cell lung cancer
positron emission tomography combined with computed tomography
therapeutic effect
カテゴリ
医学研究科
学術雑誌論文
権利
©2019 Japanese Society for Magnetic Resonance in Medicine.
CC license
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives International License.
関連情報
DOI
https://doi.org/10.2463/mrms.mp.2018-0158