神戸大学附属図書館デジタルアーカイブ
https://hdl.handle.net/20.500.14094/90007055

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メタデータID
90007055
アクセス権
open access
出版タイプ
Accepted Manuscript
タイトル
Oral administration of pineapple glucosylceramide improves defective epidermal barrier function by restoring diminished level of TGF-β in the skin
著者
Oka, Sakiko ; Ohto, Nobuaki ; Kuwahara, Hiroshige ; Mizuno, Masashi
著者名
Oka, Sakiko
著者名
Ohto, Nobuaki
著者名
Kuwahara, Hiroshige
著者ID
A1190
研究者ID
1000000212233
KUID
https://kuid-rm-web.ofc.kobe-u.ac.jp/search/detail?systemId=53bfd9d6b626d7c5520e17560c007669
著者名
Mizuno, Masashi
水野, 雅史
ミズノ, マサシ
所属機関名
農学研究科
言語
English (英語)
収録物名
European Food Research and Technology
巻(号)
246
ページ
867-874
出版者
Springer
刊行日
2020-05
公開日
2021-06-01
抄録
It was reported that oral administration of glucosylceramide (GlcCer) from plants ameliorates skin barrier function. GlcCer is a type of glycosphingolipid that exists widely as a component of the cell membrane. However, the mechanism of improvement by dietary GlcCer is not completely understood. The aim of the present study was to investigate the mechanism of GlcCer in the improvement of skin barrier function. Five-week-old male Hos:HR-1 mice were divided into three groups fed on standard diet, unsaturated fatty acids-deficient (HR-AD) diet, and HR-AD diet supplemented with 0.1% P-GlcCer diet. Skin barrier function was evaluated by transepidermal water loss (TEWL) value and wrinkle formation. The effect of transforming growth factor-β (TGF-β) on skin barrier function and collagen content in skin was examined using exogenous TGF-β and its neutralizing antibody. TEWL value and wrinkle formation were decreased by oral administration of pineapple (P)-GlcCer. Not only the TGF-β contents in serum and skin but also hydroxyproline content reduced by the HR-AD diet were restored by P-GlcCer administration. Exogenous TGF-β ameliorated both skin barrier function and collagen contents. However, the improvement of skin barrier function by P-GlcCer was cancelled and collagen content in skin was also decreased by TGF-β antibody injection. Recovery of TGF-β content by P-GlcCer contributed to the production of collagen in skin, resulting in improved skin barrier function.
キーワード
Atopic dermatitis
Collagen
Glucosylceramide
Pineapple
Transforming growth factor-β
カテゴリ
農学研究科
学術雑誌論文
権利
© Springer-Verlag GmbH Germany, part of Springer Nature 2020. This is a post-peer-review, pre-copyedit version of an article published in European Food Research and Technology. The final authenticated version is available online at: https://doi.org/10.1007/s00217-020-03454-7
関連情報
DOI
https://doi.org/10.1007/s00217-020-03454-7