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https://hdl.handle.net/20.500.14094/90007259

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メタデータID
90007259
アクセス権
open access
出版タイプ
Version of Record
タイトル
Prostaglandin E2 and its receptor EP2 trigger signaling that contributes to YAP-mediated cell competition
著者
Ishihara, Erika ; Nagaoka, Yuya ; Okuno, Toshiaki ; Kofuji, Satoshi ; Ishigami-Yuasa, Mari ; Kagechika, Hiroyuki ; Kamimura, Kenya ; Terai, Shuji ; Yokomizo, Takehiko ; Sugimoto, Yukihiko ; Fujita, Yasuyuki ; Suzuki, Akira ; Nishina, Hiroshi
著者名
Ishihara, Erika
著者名
Nagaoka, Yuya
著者名
Okuno, Toshiaki
著者名
Kofuji, Satoshi
著者名
Ishigami-Yuasa, Mari
著者名
Kagechika, Hiroyuki
著者名
Kamimura, Kenya
著者名
Terai, Shuji
著者名
Yokomizo, Takehiko
著者名
Sugimoto, Yukihiko
著者名
Fujita, Yasuyuki
著者ID
A0079
研究者ID
1000010311565
KUID
https://kuid-rm-web.ofc.kobe-u.ac.jp/search/detail?systemId=8e54b581292cf116520e17560c007669
著者名
Suzuki, Akira
鈴木, 聡
スズキ, アキラ
所属機関名
医学研究科
著者名
Nishina, Hiroshi
言語
English (英語)
収録物名
Genes to Cells
巻(号)
25(3)
ページ
197-214
出版者
Wiley
刊行日
2020-03
公開日
2020-07-17
抄録
Cell competition is a biological process by which unfit cells are eliminated from "cell society." We previously showed that cultured mammalian epithelial Madin-Darby canine kidney (MDCK) cells expressing constitutively active YAP were eliminated by apical extrusion when surrounded by "normal" MDCK cells. However, the molecular mechanism underlying the elimination of active YAP-expressing cells was unknown. Here, we used high-throughput chemical compound screening to identify cyclooxygenase-2 (COX-2) as a key molecule triggering cell competition. Our work shows that COX-2-mediated PGE2 secretion engages its receptor EP2 on abnormal and nearby normal cells. This engagement of EP2 triggers downstream signaling via an adenylyl cyclase-cyclic AMP-PKA pathway that, in the presence of active YAP, induces E-cadherin internalization leading to apical extrusion. Thus, COX-2-induced PGE(2) appears a warning signal to both abnormal and surrounding normal cells to drive cell competition.
キーワード
cell competition
COX-2
E-cadherin internalization
PGE(2)
YAP
カテゴリ
医学研究科
学術雑誌論文
権利
© 2020 The Authors. Genes to Cells published by Molecular Biology Society of Japan and John Wiley & Sons Australia, Ltd
CC license
This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
関連情報
DOI
https://doi.org/10.1111/gtc.12750