神戸大学附属図書館デジタルアーカイブ
https://hdl.handle.net/20.500.14094/90007934

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メタデータID
90007934
アクセス権
open access
出版タイプ
Accepted Manuscript
タイトル
Clinical Factors Associated With Congenital Cytomegalovirus Infection: A Cohort Study of Pregnant Women and Newborns
著者
Uchida, Akiko ; Tanimura, Kenji ; Morizane, Mayumi ; Fujioka, Kazumichi ; Morioka, Ichiro ; Oohashi, Masanobu ; Minematsu, Toshio ; Yamada, Hideto
著者ID
A2537
KUID
https://kuid-rm-web.ofc.kobe-u.ac.jp/search/detail?systemId=8c042b380a6707f2520e17560c007669
著者名
Uchida, Akiko
内田, 明子
ウチダ, アキコ
所属機関名
医学部附属病院
著者ID
A1440
研究者ID
1000080593988
KUID
https://kuid-rm-web.ofc.kobe-u.ac.jp/search/detail?systemId=7eea9da95b980b0b520e17560c007669
著者名
Tanimura, Kenji
谷村, 憲司
タニムラ, ケンジ
所属機関名
医学部附属病院
著者ID
A1404
研究者ID
1000050514692
著者名
Morizane, Mayumi
森實, 真由美
モリザネ, マユミ
所属機関名
大学院医学研究科 医科学専攻
著者ID
A0863
研究者ID
1000020568810
KUID
https://kuid-rm-web.ofc.kobe-u.ac.jp/search/detail?systemId=61a996a431fe1218520e17560c007669
著者名
Fujioka, Kazumichi
藤岡, 一路
フジオカ, カズミチ
所属機関名
医学部附属病院
著者名
Morioka, Ichiro
著者名
Oohashi, Masanobu
著者名
Minematsu, Toshio
著者ID
A0041
研究者ID
1000040220397
KUID
https://kuid-rm-web.ofc.kobe-u.ac.jp/search/detail?systemId=d4626745e9403360520e17560c007669
著者名
Yamada, Hideto
山田, 秀人
ヤマダ, ヒデト
所属機関名
医学研究科
言語
English (英語)
収録物名
Clinical Infectious Diseases
巻(号)
71(11)
ページ
2833-2839
出版者
Oxford University Press
刊行日
2019-12-02
公開日
2021-03-11
抄録
Background: The aim of this prospective cohort study was to determine clinical factors associated with the occurrence of congenital cytomegalovirus infection (cCMV) in pregnant women. Methods: Between March 2009 and November 2017, newborns born at a primary maternity hospital received polymerase chain reaction (PCR) analyses for CMV DNA in their urine with informed consent of the mothers at a low risk. Clinical data, including age, gravidity, parity, body mass index, occupation, maternal fever/flulike symptoms, pregnancy complications, gestational weeks at delivery, birth weight, and automated auditory brainstem response, were collected. Logistic regression analyses were performed to determine clinical factors associated with cCMV. Results: cCMV was diagnosed by positive PCR results of neonatal urine in 9 of 4125 pregnancies. Univariate and multivariable analyses revealed that the presence of fever/flulike symptoms (odds ratio [OR], 17.9; 95% confidence interval [CI], 3.7–86.7; P < .001) and threatened miscarriage/premature labor in the second trimester (OR, 6.0; 95% CI, 1.6–22.8; P < .01) were independent clinical factors associated with cCMV. Maternal fever/flulike symptoms or threatened miscarriage/premature labor in the second trimester had 100% sensitivity, 53.2% specificity, and a maximum Youden index of .85. Conclusions: This cohort study for the first time demonstrated that these clinical factors of pregnant women and newborns were associated with the occurrence of cCMV. This is useful information for targeted screening to assess risks of cCMV in low-risk mothers, irrespective of primary or nonprimary CMV infection.
キーワード
congenital cytomegalovirus infection
pregnancy
premature labor
risk factors
threatened miscarriage
カテゴリ
医学研究科
医学部附属病院
学術雑誌論文
権利
© The Author(s) 2019. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved.
関連情報
DOI
https://doi.org/10.1093/cid/ciz1156