Immunoglobulin fetal therapy and neonatal therapy with antiviral drugs improve neurological outcome of infants with symptomatic congenital cytomegalovirus infection

Tanimura, Kenji; Shi, Yutoku; Uchida, Akiko; Uenaka, Mizuki; Imafuku, Hitomi; Ikuta, Toshihiko; Fujioka, Kazumichi; Morioka, Ichiro; Deguchi, Masashi; Minematsu, Toshio; Yamada, Hideto

https://hdl.handle.net/20.500.14094/90007953

このアイテムのアクセス数:116件（2024-12-22 16:00 集計）

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メタデータID	90007953
アクセス権	open access
出版タイプ	Accepted Manuscript
タイトル	Immunoglobulin fetal therapy and neonatal therapy with antiviral drugs improve neurological outcome of infants with symptomatic congenital cytomegalovirus infection
著者	Tanimura, Kenji ; Shi, Yutoku ; Uchida, Akiko ; Uenaka, Mizuki ; Imafuku, Hitomi ; Ikuta, Toshihiko ; Fujioka, Kazumichi ; Morioka, Ichiro ; Deguchi, Masashi ; Minematsu, Toshio ; Yamada, Hideto
著者ID A1440 研究者ID 1000080593988 KUID https://kuid-rm-web.ofc.kobe-u.ac.jp/search/detail?systemId=7eea9da95b980b0b520e17560c007669 著者名 Tanimura, Kenji 谷村, 憲司タニムラ, ケンジ所属機関名医学部附属病院
著者ID A2541 KUID https://kuid-rm-web.ofc.kobe-u.ac.jp/search/detail?systemId=764d2b94711161a4520e17560c007669 著者名 Shi, Yutoku 施, 裕徳シ, ユウトク所属機関名医学部附属病院
著者ID A2537 KUID https://kuid-rm-web.ofc.kobe-u.ac.jp/search/detail?systemId=8c042b380a6707f2520e17560c007669 著者名 Uchida, Akiko 内田, 明子ウチダ, アキコ所属機関名医学部附属病院
著者ID A2071 著者名 Uenaka, Mizuki 上中, 美月ウエナカ, ミヅキ所属機関名医学部附属病院
著者ID A1494 研究者ID 1000060726131 KUID https://kuid-rm-web.ofc.kobe-u.ac.jp/search/detail?systemId=193a94811ad06349520e17560c007669 著者名 Imafuku, Hitomi 今福, 仁美イマフク, ヒトミ所属機関名医学部附属病院
著者ID A2530 研究者ID 1000040814588 著者名 Ikuta, Toshihiko 生田, 寿彦イクタ, トシヒコ所属機関名医学部附属病院
著者ID A0863 研究者ID 1000020568810 KUID https://kuid-rm-web.ofc.kobe-u.ac.jp/search/detail?systemId=61a996a431fe1218520e17560c007669 著者名 Fujioka, Kazumichi 藤岡, 一路フジオカ, カズミチ所属機関名医学部附属病院
著者ID A1383 研究者ID 1000080437467 著者名 Morioka, Ichiro 森岡, 一朗モリオカ, イチロウ所属機関名医学研究科
著者ID A1376 研究者ID 1000050403291 KUID https://kuid-rm-web.ofc.kobe-u.ac.jp/search/detail?systemId=9c3a88fdc801880c520e17560c007669 著者名 Deguchi, Masashi 出口, 雅士デグチ, マサシ所属機関名医学研究科
著者名 Minematsu, Toshio
著者ID A0041 研究者ID 1000040220397 著者名 Yamada, Hideto 山田, 秀人ヤマダ, ヒデト所属機関名医学研究科
言語	English (英語)
収録物名	Journal of Reproductive Immunology
巻(号)	143
ページ	103263
出版者	Elsevier B.V.
刊行日	2021-02
公開日	2022-03-01
抄録	Infants with symptomatic congenital cytomegalovirus infection (cCMV) suffer from long-term sequelae. This study aimed at evaluating the efficacy of combining immunoglobulin (Ig) fetal therapy (FT) and neonatal therapy (NT) with antiviral drugs to improve neurological outcomes of affected infants. Women whose fetuses had symptomatic cCMV received Ig injection into the fetal peritoneal cavity and/or maternal blood as FT, while affected newborns received oral valganciclovir or intravenous ganciclovir as NT. We compared the neurological outcomes at ≥18 months old between infants receiving FT with or without NT (FT group) and those receiving NT only (NT group). From 2009-2019, 15 women whose fetuses had symptomatic cCMV received FT, while 19 newborns received NT only. In FT group, two newborns died, and two were <18 months old. Neurological outcomes of the remaining 11 infants in FT group were as follows: normal 45.5 %, mild impairments 36.4 %, and severe impairments 18.2 %. In NT group, one newborn died, one's parents refused the follow-up, one was <18 months old, and two had only chorioretinitis as symptoms. Neurological outcomes of the remaining 14 infants in NT group were as follows: normal 21.4 %, mild impairments 14.3 %, and severe impairments 64.3 %. The proportion of infants with severe impairments in FT group was significantly lower than that in NT group (18.2 % vs 64.3 %, p < 0.05). This is the first trial demonstrating that the combination of Ig FT and NT with antiviral drugs may be more effective in improving neurological outcomes of newborns with symptomatic cCMV as compared to NT only.
キーワード	Antiviral drugs
	Congenital cytomegalovirus infection
	Fetal therapy
	Immunoglobulin
	Neonatal therapy
カテゴリ	医学研究科
	医学部附属病院
	学術雑誌論文
権利	© 2020 Elsevier B.V.
権利	This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
関連情報	DOI https://doi.org/10.1016/j.jri.2020.103263

資源タイプ	journal article
ISSN	0165-0378　OPACで所蔵を検索　 CiNiiで学外所蔵を検索
eISSN	1872-7603　OPACで所蔵を検索　 CiNiiで学外所蔵を検索
NCID	AA00259245　OPACで所蔵を検索　 CiNiiで表示

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