神戸大学附属図書館デジタルアーカイブ
https://hdl.handle.net/20.500.14094/90008035

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メタデータID
90008035
アクセス権
open access
出版タイプ
Version of Record
タイトル
FGF-23 from erythroblasts promotes hematopoietic progenitor mobilization
著者
Ishii, Shinichi ; Suzuki, Tomohide ; Wakahashi, Kanako ; Asada, Noboru ; Kawano, Yuko ; Kawano, Hiroki ; Sada, Akiko ; Minagawa, Kentaro ; Nakamura, Yukio ; Mizuno, Seiya ; Takahashi, Satoru ; Matsui, Toshimitsu ; Katayama, Yoshio
著者名
Ishii, Shinichi
著者名
Suzuki, Tomohide
著者名
Wakahashi, Kanako
著者名
Asada, Noboru
著者名
Kawano, Yuko
著者名
Kawano, Hiroki
著者名
Sada, Akiko
著者名
Minagawa, Kentaro
著者名
Nakamura, Yukio
著者名
Mizuno, Seiya
著者名
Takahashi, Satoru
著者名
Matsui, Toshimitsu
著者ID
A1381
研究者ID
1000080397885
KUID
https://kuid-rm-web.ofc.kobe-u.ac.jp/search/detail?systemId=6d25cff00fdea105520e17560c007669
著者名
Katayama, Yoshio
片山, 義雄
カタヤマ, ヨシオ
所属機関名
医学部附属病院
収録物名
Blood
巻(号)
137(11)
ページ
1457-1467
出版者
American Society of Hematology
刊行日
2021-03-18
公開日
2022-04-01
抄録
Fibroblast growth factor 23 (FGF-23) hormone is produced by bone-embedded osteocytes and regulates phosphate homeostasis in kidneys. We found that administration of granulocyte colony-stimulating factor (G-CSF) to mice induced a rapid, substantial increase in FGF-23 messenger RNA in bone marrow (BM) cells. This increase originated mainly from CD45−Ter119+CD71+ erythroblasts. FGF-23 protein in BM extracellular fluid was markedly increased during G-CSF–induced hematopoietic progenitor cell (HPC) mobilization, but remained stable in the blood, with no change in the phosphate level. Consistent with the BM hypoxia induced by G-CSF, low oxygen concentration induced FGF-23 release from human erythroblast HUDEP-2 cells in vitro. The efficient mobilization induced by G-CSF decreased drastically in both FGF-23−/− and chimeric mice with FGF-23 deficiency, only in hematopoietic cells, but increased in osteocyte-specific FGF-23−/− mice. This finding suggests that erythroblast-derived, but not bone-derived, FGF-23 is needed to release HPCs from BM into the circulation. Mechanistically, FGF-23 did not influence CXCL-12 binding to CXCR-4 on progenitors but interfered with their transwell migration toward CXCL-12, which was canceled by FGF receptor inhibitors. These results suggest that BM erythroblasts facilitate G-CSF–induced HPC mobilization via FGF-23 production as an intrinsic suppressor of chemoattraction.
キーワード
erythroblasts
fibroblast growth factor 23
granulocyte colony-stimulating factor
hypoxia
mice
phosphates
osteocytes
カテゴリ
医学部附属病院
学術雑誌論文
権利
This research was originally published in Blood. Shinichi I., Tomohide S., Kanako W., Noboru A., Yuko K., Hiroki K., Akiko S., Kentaro M., Yukio N., Seiya M., Satoru T., Toshimitsu M., Yoshio K. FGF-23 from erythroblasts promotes hematopoietic progenitor mobilization. Blood. 2021;137(11):1457–1467. © 2021 by The American Society of Hematology