Complete response in a patient with lung cancer suffering from three pembrolizumab-induced immune-related adverse events including retinal vasculitis

Mimura, Chihiro; Tachihara, Motoko; Kusuhara, Sentaro; Fukuoka, Hidenori; Nishimura, Yoshihiro

https://hdl.handle.net/20.500.14094/90008147

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メタデータID	90008147
アクセス権	open access
出版タイプ	Version of Record
タイトル	Complete response in a patient with lung cancer suffering from three pembrolizumab-induced immune-related adverse events including retinal vasculitis
著者	Mimura, Chihiro ; Tachihara, Motoko ; Kusuhara, Sentaro ; Fukuoka, Hidenori ; Nishimura, Yoshihiro
著者名 Mimura, Chihiro
著者ID A1452 研究者ID 1000040448626 KUID https://kuid-rm-web.ofc.kobe-u.ac.jp/search/detail?systemId=8a84f5066adebfb6520e17560c007669 著者名 Tachihara, Motoko 立原, 素子タチハラ, モトコ所属機関名医学研究科
著者ID A1380 研究者ID 1000040437463 KUID https://kuid-rm-web.ofc.kobe-u.ac.jp/search/detail?systemId=32b946773fbb21da520e17560c007669 著者名 Kusuhara, Sentaro 楠原, 仙太郎クスハラ, センタロウ所属機関名医学研究科
著者ID A1463 研究者ID 1000080622068 KUID https://kuid-rm-web.ofc.kobe-u.ac.jp/search/detail?systemId=7a6e73f7fe330695520e17560c007669 著者名 Fukuoka, Hidenori 福岡, 秀規フクオカ, ヒデノリ所属機関名医学部附属病院
著者ID A0759 研究者ID 1000020291453 著者名 Nishimura, Yoshihiro 西村, 善博ニシムラ, ヨシヒロ所属機関名医学部附属病院
言語	English (英語)
収録物名	Respirology Case Reports
巻(号)	9(4)
ページ	e00730
出版者	Wiley
刊行日	2021-04
公開日	2021-04-20
抄録	A 71-year-old man was diagnosed with squamous cell lung carcinoma with high expression of programmed cell death ligand 1 (PDL1) (cT4N1M1b stage IVA). He was treated with pembrolizumab, but 14 days later, he suffered from pembrolizumab-related retinal vasculitis as an immune-related adverse event (irAE). The symptoms were ameliorated by oral corticosteroids. We succeeded in switching to topical treatment as early as possible with the help of an ophthalmologist. Six months after discontinuing treatment with oral prednisolone, hypophysitis and thyroiditis occurred in six cycles of pembrolizumab. Finally, he suffered from three irAEs, but the antitumour effect resulted in a remarkable response.
キーワード	Hypophysitis
	immune-related adverse events
	lung cancer
	retinal vasculitis
	thyroiditis
カテゴリ	医学研究科
	医学部附属病院
	学術雑誌論文
権利	© 2021 The Authors. Respirology Case Reports published by John Wiley & Sons Australia, Ltd on behalf of The Asian Pacific Society of Respirology.
権利	This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
関連情報	DOI https://doi.org/10.1002/rcr2.730

資源タイプ	journal article
eISSN	2051-3380　OPACで所蔵を検索　 CiNiiで学外所蔵を検索

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