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https://hdl.handle.net/20.500.14094/90008171

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メタデータID
90008171
アクセス権
open access
出版タイプ
Version of Record
タイトル
The Dominance of CRF01_AE and the Emergence of Drug Resistance Mutations Among Antiretroviral Therapy-Experienced, HIV-1-infected Individuals in Medan, Indonesia
著者
Indriati, Dwi W. ; Witaningrum, Adiana M. ; Yunifiar, M. Qushai ; Khairunisa, Siti Q. ; Ueda, Shuhei ; Kotaki, Tomohiro ; Nasronudin ; Kameoka, Masanori
著者名
Indriati, Dwi W.
著者名
Witaningrum, Adiana M.
著者名
Yunifiar, M. Qushai
著者名
Khairunisa, Siti Q.
著者名
Ueda, Shuhei
著者ID
A1352
研究者ID
1000010758816
著者名
Kotaki, Tomohiro
小瀧, 将裕
コタキ, トモヒロ
所属機関名
保健学研究科
著者名
Nasronudin
著者ID
A0045
研究者ID
1000060281838
KUID
https://kuid-rm-web.ofc.kobe-u.ac.jp/search/detail?systemId=01cae9e1f2290a00520e17560c007669
著者名
Kameoka, Masanori
亀岡, 正典
カメオカ, マサノリ
所属機関名
保健学研究科
言語
English (英語)
収録物名
Acta Medica Indonesiana
巻(号)
52(4)
ページ
366-374
出版者
The Indonesian Society of Internal Medicine
刊行日
2020-10
公開日
2021-04-21
抄録
Background: human immunodeficiency virus type 1 (HIV-1) infection is a serious public health threat worldwide. Medan is one example of big cities in Indonesia with a high prevalence of HIV-1 infection; however, quite a limited study had conducted for detecting the circulation of HIV-1 subtypes in Medan. In addition, a serious factor that can implicate the treatment of HIV-1-infected individuals is the emergence of drug resistance mutations. Thus, the information on HIV-1 infection is important to improve the treatment for infected individuals. Methods: sixty-seven antiretroviral therapy-experienced, HIV-1-infected individuals were recruited for this study. HIV-1 pol genes encoding protease (PR genes) and reverse transcriptase (RT gene), as well as env and gag genes, were amplified from DNA derived from peripheral blood samples. HIV-1 subtyping was conducted to study the dominant HIV-1 subtype circulating in the region. In addition, the emergence of drug resistance mutations was analyzed based on the guidelines published by the International Antiviral Society-United States of America (IAS-USA). Results: the dominant HIV-1 subtype found in Medan was CRF01_AE (77.6%). In addition, another subtype and recombinant viruses such as recombinants between CRF01_AE and subtype B (12.2%), subtype B (4.1%), and CRF02_AG (4.1%) were also found. Drug resistance-associated major mutations were found in 21.6% (8/37) of RT genes and 3.1% (1/32) of PR genes studied. Conclusion: our study showed that the dominant subtype found in ART-experienced, HIV-1-infected individuals residing in Medan was CRF01_AE. The emergence of drug resistance mutations in RT and PR genes indicated the importance to monitor the prevalence of drug resistance mutations among HIV-1-infected individuals in Medan.
キーワード
HIV-1
CRF01_AE
antiretroviral therapy
drug resistance
Medan
カテゴリ
保健学研究科
学術雑誌論文
権利
(c) 2020 Acta Medica Indonesiana.
CC license
This work is licensed under a Creative Commons Attribution 4.0 International License.