神戸大学附属図書館デジタルアーカイブ
https://hdl.handle.net/20.500.14094/90008237

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メタデータID
90008237
アクセス権
open access
出版タイプ
Accepted Manuscript
タイトル
Improved Fc epsilon RI-Mediated CD203c Basophil Responsiveness Reflects Rapid Responses to Omalizumab in Chronic Spontaneous Urticaria
著者
Oda, Yoshiko ; Fukunaga, Atsushi ; Washio, Ken ; Imamura, Shinya ; Mizuno, Mayuko ; Hatakeyama, Mayumi ; Ogura, Kanako ; Nishigori, Chikako
著者ID
A2852
研究者ID
1000090874082
KUID
https://kuid-rm-web.ofc.kobe-u.ac.jp/search/detail?systemId=21096bf9ecf9c05d520e17560c007669
著者名
Oda, Yoshiko
織田, 好子
オダ, ヨシコ
所属機関名
医学研究科
著者ID
A0799
研究者ID
1000010467649
KUID
https://kuid-rm-web.ofc.kobe-u.ac.jp/search/detail?systemId=894995f3b83db350520e17560c007669
著者名
Fukunaga, Atsushi
福永, 淳
フクナガ, アツシ
所属機関名
医学研究科
著者ID
A2357
研究者ID
1000080770388
著者名
Washio, Ken
鷲尾, 健
ワシオ, ケン
所属機関名
医学部附属病院
著者名
Imamura, Shinya
著者名
Mizuno, Mayuko
著者名
Hatakeyama, Mayumi
著者ID
A1459
研究者ID
1000070619155
著者名
Ogura, Kanako
小倉, 香奈子
オグラ, カナコ
所属機関名
医学部附属病院
著者ID
A0395
研究者ID
1000050198454
KUID
https://kuid-rm-web.ofc.kobe-u.ac.jp/search/detail?systemId=e6f42019bd45236f520e17560c007669
著者名
Nishigori, Chikako
錦織, 千佳子
ニシゴリ, チカコ
所属機関名
医学研究科
言語
English (英語)
収録物名
Journal of Allergy and Clinical Immunology: In Practice
巻(号)
9(3)
ページ
1166-1176
出版者
Elsevier
刊行日
2021-03
公開日
2022-04-01
抄録
Background: Omalizumab is effective in patients with chronic spontaneous urticaria (CSU) although its mechanism of action is poorly understood. Several studies reported that decreased high-affinity IgE receptor (FcεRI)-mediated histamine release and/or responsiveness was characteristic of basophils in patients with CSU. However, few studies have focused on the relationship between changes in basophil responsiveness via FcεRI after omalizumab treatment and the therapeutic effect in patients with CSU. Objective: To assess basophil responsiveness via FcεRI stimulation, as well as FcεRI expression and IgE binding on blood basophils from patients with CSU before and after omalizumab treatment and its possible association with the clinical response. Methods: We analyzed 34 patients with CSU treated with omalizumab who were categorized as fast responders (FRs) (n = 20) and non or slow responders (N/SRs) (n = 14). CD203c expression induced by FcεRI stimulation, and IgE and FcεRI expressions on blood basophils from patients with CSU before and after omalizumab treatment were analyzed. Basophil responsiveness via FcεRI stimulation was observed in vitro using basophils pretreated with omalizumab. Results: FRs had increased CD203c responsiveness after treatment with omalizumab compared with N/SRs. This improvement of basophil responsiveness via FcεRI stimulation in FRs was not observed in peripheral blood basophils preincubated with omalizumab in vitro, suggesting that omalizumab does not directly affect circulating pre-existing abnormal basophils. Conclusion: Increased basophil responsiveness via FcεRI after omalizumab treatment is associated with the therapeutic effect and mechanism of action of omalizumab.
キーワード
Chronic spontaneous urticaria
Omalizumab
CD203c
Basophil activation test
カテゴリ
医学研究科
医学部附属病院
学術雑誌論文
権利
© 2020 American Academy of Allergy, Asthma & Immunology.
CC license
This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
関連情報
DOI
https://doi.org/10.1016/j.jaip.2020.08.048