The Histopathologic and Radiologic Features of T2-FLAIR Mismatch Sign in IDH-Mutant 1p/19q Non-codeleted Astrocytomas

Fujita, Yuichi; Nagashima, Hiroaki; Tanaka, Kazuhiro; Hashiguchi, Mitsuru; Hirose, Takanori; Itoh, Tomoo; Sasayama, Takashi

https://hdl.handle.net/20.500.14094/90008312

このアイテムのアクセス数:184件（2025-08-02 21:36 集計）

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メタデータID	90008312
アクセス権	open access
出版タイプ	Accepted Manuscript
タイトル	The Histopathologic and Radiologic Features of T2-FLAIR Mismatch Sign in IDH-Mutant 1p/19q Non-codeleted Astrocytomas
著者	Fujita, Yuichi ; Nagashima, Hiroaki ; Tanaka, Kazuhiro ; Hashiguchi, Mitsuru ; Hirose, Takanori ; Itoh, Tomoo ; Sasayama, Takashi
著者ID A2766 研究者ID 1000040895132 KUID https://kuid-rm-web.ofc.kobe-u.ac.jp/search/detail?systemId=4e9fdedf4acdd6e5520e17560c007669 著者名 Fujita, Yuichi 藤田, 祐一フジタ, ユウイチ所属機関名医学部附属病院
著者ID A2958 研究者ID 1000000794950 KUID https://kuid-rm-web.ofc.kobe-u.ac.jp/search/detail?systemId=8a1f93f3bbc07e69520e17560c007669 著者名 Nagashima, Hiroaki 長嶋, 宏明ナガシマ, ヒロアキ所属機関名医学研究科
著者ID A2253 研究者ID 1000070467661 KUID https://kuid-rm-web.ofc.kobe-u.ac.jp/search/detail?systemId=a940aff19fda4c41520e17560c007669 著者名 Tanaka, Kazuhiro 田中, 一寛タナカ, カズヒロ所属機関名医学部附属病院
著者名 Hashiguchi, Mitsuru
著者ID A1681 研究者ID 1000000181206 KUID https://kuid-rm-web.ofc.kobe-u.ac.jp/search/detail?systemId=136fa7cc8b3175a0520e17560c007669 著者名 Hirose, Takanori 廣瀬, 隆則ヒロセ, タカノリ所属機関名医学研究科
著者ID A0047 研究者ID 1000020301880 KUID https://kuid-rm-web.ofc.kobe-u.ac.jp/search/detail?systemId=f4a9ec44690e3908520e17560c007669 著者名 Itoh, Tomoo 伊藤, 智雄イトウ, トモオ所属機関名医学部附属病院
著者ID A1382 研究者ID 1000010379399 KUID https://kuid-rm-web.ofc.kobe-u.ac.jp/search/detail?systemId=b8758a4d12d875ed520e17560c007669 著者名 Sasayama, Takashi 篠山, 隆司ササヤマ, タカシ所属機関名医学研究科
言語	English (英語)
収録物名	World Neurosurgery
巻(号)	149
ページ	E253-E260
出版者	Elsevier
刊行日	2021-05
公開日	2022-06-01
抄録	Objective: The T2-FLAIR mismatch sign is a useful imaging sign in clinical magnetic resonance imaging studies for detecting isocitrate dehydrogenase (IDH)-mutant 1p/19q non-codeleted astrocytomas. However, the association between the mismatch sign and pathologic findings is poorly understood. Therefore, the aim of this study was to elucidate the relationship of histopathologic and radiologic features with the mismatch sign in IDH-mutant 1p/19q non-codeleted astrocytomas. Methods: We divided 17 IDH-mutant 1p/19q non-codeleted patients into 2 groups according to mismatch sign presence (WITH, n = 9; WITHOUT, n = 8) and retrospectively analyzed their pathologic findings and apparent diffusion coefficient (ADC) values. We also compared these findings between the tumor Core (central area) and Rim (marginal area). Results: In the pathologic analysis, Core of the WITH group contained numerous microcysts whereas Rim had abundant neuroglial fibrils and cellularity. In contrast, Core of the WITHOUT group had highly concentrated neuroglial fibrils. In ADC analysis, Core of the WITH group had significantly higher ADC values compared with Rim (P < 0.001). However, there was no significant difference between Core and Rim in the WITHOUT group (P = 0.12). The WITH group had a significantly higher Core/Rim ratio of ADC values compared with the WITHOUT group (P < 0.001). Conclusions: This study provides evidence that a region-dependent microstructural difference could reflect the mismatch sign in IDH-mutant 1p/19q non-codeleted astrocytomas. Core of the mismatch sign characteristically had microcystic changes accompanied by higher ADC values, whereas Rim had abundant neuroglial fibrils and cellularity accompanied by lower ADC values.
キーワード	1p/19q codeletion
	Apparent diffusion coefficient
	Astrocytoma
	Glioma
	IDH mutation
	T2-FLAIR mismatch sign
カテゴリ	医学研究科
	医学部附属病院
	学術雑誌論文
権利	© 2021 Elsevier Inc.
権利	This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
関連情報	DOI https://doi.org/10.1016/j.wneu.2021.02.042

資源タイプ	journal article
ISSN	1878-8750　OPACで所蔵を検索　 CiNiiで学外所蔵を検索
NCID	AA12469471　OPACで所蔵を検索　 CiNiiで表示

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