90008391

open access

Version of Record

Substrate-supported Model Membrane as a Versatile Analytical/Biosensing Platform

English (英語)

Analytical Sciences

37(5)

683-689

Japan Society for Analytical Chemistry

2021-05

2021-07-02

Biological membranes composed of a lipid bilayer and associated proteins work as a platform for highly selective and sensitive detection in nature. Substrate-supported lipid bilayers (SLBs) are a model system of the biological membrane that are mechanically stable, accessible to highly sensitive analytical techniques, and amenable to micro-fabrication, such as patterning. The surface of SLBs can effectively suppress the non-specific binding of proteins, and enhance selective detection by specific interactions. These features render SLBs highly attractive for the development of devices that utilize artificially mimicked cellular functions. Furthermore, SLBs can be combined with nanoscopic spaces, such as nano-channels and nano-pores, that can reduce the detection volume and suppress the non-specific background noise, enhancing the signal-to-background noise (S/B) ratio. SLBs therefore provide promising platforms for a wide range of biomedical and environmental analyses.

nanofluidics

学術雑誌論文

© 2021 by The Japan Society for Analytical Chemistry