90008404

open access

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Development of Magnetic Particle Distribution Imaging Using Magnetic Field Reconstruction for Biopsy of the Sentinel Lymph Node

English (英語)

Magnetochemistry

7(6)

85

MDPI

2021-06

2021-07-05

The sentinel lymph node is the first lymph-node-draining cancer metastasis. The identification of the sentinel lymph node using magnetic particles and a magnetic sensor has attracted attention in recent years, as this method is less invasive than the conventional method of radiotracer injection. However, the development of a two-dimensional measurement method for sentinel lymph nodes using magnetic nanoparticles remains an issue. In the present study, a method and apparatus for the two-dimensional imaging of magnetic particle distribution were developed to detect a lymph node with magnetic particles concentrated within lymphoid tissues. The method comprises the reconstruction of the magnetic field measured with a high-sensitivity magnetic sensor and with a magnetic detection ability of 2 nT/√Hz at 100 Hz (5 nT/√Hz at 1 Hz). The proposed system measures the two-dimensional magnetic field distribution in an area of up to 25 x 25 mm(2) using a coil generating a 0.77 mT external magnetic field applied to the measurement target. The improved spatial resolution of the images makes it possible to use two-dimensional imaging for diagnostics of breast cancer metastases.

spatial resolution

学術雑誌論文

This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).