Albumin-Derived NLR Score is a Novel Prognostic Marker for Esophageal Squamous Cell Carcinoma

Abe, Tomoki; Oshikiri, Taro; Goto, Hironobu; Kato, Takashi; Horikawa, Manabu; Sawada, Ryuichiro; Harada, Hitoshi; Urakawa, Naoki; Hasegawa, Hiroshi; Kanaji, Shingo; Yamashita, Kimihiro; Matsuda, Takeru; Kakeji, Yoshihiro

https://hdl.handle.net/20.500.14094/90009163

このアイテムのアクセス数:213件（2025-06-17 14:25 集計）

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メタデータID	90009163
アクセス権	open access
出版タイプ	Accepted Manuscript
タイトル	Albumin-Derived NLR Score is a Novel Prognostic Marker for Esophageal Squamous Cell Carcinoma
著者	Abe, Tomoki ; Oshikiri, Taro ; Goto, Hironobu ; Kato, Takashi ; Horikawa, Manabu ; Sawada, Ryuichiro ; Harada, Hitoshi ; Urakawa, Naoki ; Hasegawa, Hiroshi ; Kanaji, Shingo ; Yamashita, Kimihiro ; Matsuda, Takeru ; Kakeji, Yoshihiro
著者名 Abe, Tomoki
著者ID A0849 研究者ID 1000030771498 KUID https://kuid-rm-web.ofc.kobe-u.ac.jp/search/detail?systemId=b9ef293e7421679f520e17560c007669 著者名 Oshikiri, Taro 押切, 太郎オシキリ, タロウ所属機関名医学研究科
著者名 Goto, Hironobu
著者名 Kato, Takashi
著者名 Horikawa, Manabu
著者名 Sawada, Ryuichiro
著者ID A3023 KUID https://kuid-rm-web.ofc.kobe-u.ac.jp/search/detail?systemId=6890d97a51055143520e17560c007669 著者名 Harada, Hitoshi 原田, 仁ハラダ, ヒトシ所属機関名医学部附属病院
著者ID A2526 研究者ID 1000020647763 KUID https://kuid-rm-web.ofc.kobe-u.ac.jp/search/detail?systemId=cee872a7fac91c14520e17560c007669 著者名 Urakawa, Naoki 裏川, 直樹ウラカワ, ナオキ所属機関名医学部附属病院
著者ID A1558 研究者ID 1000050529542 KUID https://kuid-rm-web.ofc.kobe-u.ac.jp/search/detail?systemId=70d816578161532d520e17560c007669 著者名 Hasegawa, Hiroshi 長谷川, 寛ハセガワ, ヒロシ所属機関名医学部附属病院
著者ID A1519 研究者ID 1000010637052 KUID https://kuid-rm-web.ofc.kobe-u.ac.jp/search/detail?systemId=508b6461f962866e520e17560c007669 著者名 Kanaji, Shingo 金治, 新悟カナジ, シンゴ所属機関名医学部附属病院
著者ID A1436 研究者ID 1000080535427 KUID https://kuid-rm-web.ofc.kobe-u.ac.jp/search/detail?systemId=a1b771806c49baeb520e17560c007669 著者名 Yamashita, Kimihiro 山下, 公大ヤマシタ, キミヒロ所属機関名医学部附属病院
著者ID A1537 研究者ID 1000030782734 KUID https://kuid-rm-web.ofc.kobe-u.ac.jp/search/detail?systemId=fcf7c52c66d495fa520e17560c007669 著者名 Matsuda, Takeru 松田, 武マツダ, タケル所属機関名医学研究科
著者ID A1706 研究者ID 1000080284488 KUID https://kuid-rm-web.ofc.kobe-u.ac.jp/search/detail?systemId=2901d33e92e00ca4520e17560c007669 著者名 Kakeji, Yoshihiro 掛地, 吉弘カケジ, ヨシヒロ所属機関名医学研究科
言語	English (英語)
収録物名	Annals of Surgical Oncology
巻(号)	29(4)
ページ	2663-2671
出版者	Springer
刊行日	2022-04
公開日	2023-05-01
抄録	Background Multidisciplinary treatment for esophageal squamous cell carcinoma (ESCC) has improved outcomes, but the prognosis for ESCC remains poor. Nutritional and inflammatory indicators are reported to be associated with cancer prognosis. The combination of albumin and the derived neutrophil-to-lymphocyte ratio (Alb-dNLR) score was established to measure the immune system and nutritional status. The authors hypothesized that the Alb-dNLR score could be a new reliable prognostic factor for ESCC patients. Methods The study evaluated 269 patients who underwent esophagectomy between April 2010 and March 2018, including 185 patients who received neoadjuvant chemotherapy. The Alb-dNLR score was calculated using serum albumin and the dNLR. The dNLR was calculated as neutrophils to (leukocyte-neutrophil count). The cutoff values of the albumin and dNLR for overall survival (OS) were determined using the receiver operating characteristic curve. Patients were divided into “high” and “low” groups according to the Alb-dNLR score. Results A high Alb-dNLR score was found in 61 cases (22.7%). The 5-year OS was 34% in the high Alb-dNLR group and 66.2% in the low Alb-dNLR group (p < 0.0001). The 5-year cause-specific survival (CSS) was 51.5% in the high Alb-dNLR group and 74.7% in the low Alb-dNLR group (p < 0.0001). Multivariate analyses demonstrated that the Alb-dNLR score was an independent prognostic factor for OS (hazard ratio [HR], 2.198; 95% confidence interval [CI], 1.460–3.263; p = 0.0002) and CSS (HR, 1.733; 95% CI, 1.035–2.835; p = 0.0371). Conclusions The Alb-dNLR score is an extremely useful, easy-to-use parameter to predict OS and CSS for ESCC patients.
カテゴリ	医学研究科
	医学部附属病院
	学術雑誌論文
権利	This version of the article has been accepted for publication, after peer review (when applicable) and is subject to Springer Nature's AM terms of use, but is not the Version of Record and does not reflect post-acceptance improvements, or any corrections. The Version of Record is available online at: https://doi.org/10.1245/s10434-021-11012-y
関連情報	DOI https://doi.org/10.1245/s10434-021-11012-y

資源タイプ	journal article
ISSN	1068-9265　OPACで所蔵を検索　 CiNiiで学外所蔵を検索
eISSN	1534-4681　OPACで所蔵を検索　 CiNiiで学外所蔵を検索
NCID	AA11016573　OPACで所蔵を検索　 CiNiiで表示

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