A Mechanism of Cisplatin Action : Antineoplastic Effect through Inhibition of Neovascularization

Yoshikawa, Atsushi; Saura, Ryuichi; Matsubara, Tsukasa; Mizuno, Kosaku

https://hdl.handle.net/20.500.14094/E0000984

このアイテムのアクセス数:57件（2026-08-11 08:38 集計）

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43-3-4_109-120 (fulltext)	pdf	1.23 MB	93

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メタデータID	E0000984
アクセス権	open access
出版タイプ	Version of Record
タイトル	A Mechanism of Cisplatin Action : Antineoplastic Effect through Inhibition of Neovascularization
タイトル	A Mechanism of Cisplatin Action : Antineoplastic Effect through Inhibition of Neovascularization
著者	Yoshikawa, Atsushi ; Saura, Ryuichi ; Matsubara, Tsukasa ; Mizuno, Kosaku
著者名 Yoshikawa, Atsushi
著者名 Saura, Ryuichi
著者名 Matsubara, Tsukasa
著者名 Mizuno, Kosaku
言語	English (英語)
収録物名	The Kobe journal of the medical sciences
巻(号)	43(3)
ページ	109-120
刊行日	1997-08
抄録	Though cisplatin (cis-diamminedichloroplatinum; CDDP) has been widely used for the treatment of malignant tumors, the mechanism of its action has not been well understood. Neovascularization, which accompanies tumor growth and metastasis, is required for cell proliferation in order to supply both oxygen and nutrients. We have studied in this investigation the effect of CDDP on endothelial cell (EC) proliferation in vitro and on rabbit corneal neovascularization in vivo. DNA synthesis of human umbilical EC was inhibited by CDDP in a dose-dependent fashion. Significant inhibition was observed at concentration over 10(-8) M, which is attainable in the serum of treated patients. Rabbit corneal neovascularization in vivo was also suppressed by intravenous injection of 0.5 mg/kg of CDDP for 10 days. These results suggest that CDDP might have an indirect anti-neoplastic effect through the suppression of neovascularization required for the tumor growth.
カテゴリ	The Kobe journal of the medical sciences ＞ 43巻＞ 43巻3号（1997-08）
カテゴリ	紀要論文

資源タイプ	departmental bulletin paper
ISSN	0023-2513　OPACで所蔵を検索　 CiNiiで学外所蔵を検索
NCID	AA00711740　OPACで所蔵を検索　 CiNiiで表示

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